VITAMIN D AND ITS ROLE IN THE OCCURRENCE OF OSTEOARTHRITIS IN WOMEN OF DIFFERENT AGE CATEGORIES
Keywords:
osteoarthritis, vitamin D, interleukins, cytokine imbalanceAbstract
Introduction: Osteoarthritis (OA) is a common degenerative inflammatory disease of the joints that develops as a result of cellular stress and maladaptive regeneration processes, leading to loss of function and the need for total joint replacement. Vitamin D is currently considered a steroid hormone that plays an important role in bone tissue homeostasis. Thus, it directly regulates calcium and phosphorus metabolism, promoting healthy bone mineralization, growth and remodeling. Vitamin D deficiency has been shown to be associated with a number of immunological disorders and may be an environmental risk factor for the development of OA.
Objective: to research the role of vitamin D in the development and progression of osteoarthritis in women.
Materials and methods: Clinical studies consisted of identifying complaints, familiarizing with case histories, studying anamnestic data and features of the course of the disease in different age categories of patients. It also included clinical, instrumental and laboratory data, in particular the determination of the blood level of vitamin D and proinflammatory interleukins (IL-1 and TNF-α IL-4 and IL-10).
Results of the study: The obtained data indicate that women with osteoarthritis more often have hypercholesterolemia and anxiety-depressive syndrome in the older age group. The level of vitamin D was reduced in 38-39% of the subjects, which confirms its importance in the pathogenesis of the disease.
Conclusion: Thus, to identify patients at risk of OA progression, it is necessary to analyze etiopathogenetic risk factors such as excess weight and synovitis, concomitant pathologies, cytokine imbalance, and blood vitamin D levels.
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