PATHOGENETIC ROLE OF DISORDERS IN THE CYTOKINE SYSTEM IN NON-SPECIFIC INTERSTITIAL PNEUMONIA
Keywords:
Non-specific interstitial pneumonia, cytokines, serum, imbalanceAbstract
As it turns out nonspecific interstitial pneumonia (NSIP) is a class of idiopathic interstitial pneumonia (IIP). NSIP is a chronic interstitial pneumonia with a homogeneous pattern of interstitial fibrosis and inflammation. It is nonspecific because NSIP does not have the histopathological features of other IIP subtypes. NSIP usually has bilateral lung involvement and may be more common in the lower lobes. NSIP is an orphan disease, affecting a small proportion of the population, and is rare. This is more common than nonspecific interstitial pneumonia (50% to 60%) and acute interstitial disease, which is more common than acute interstitial pneumonia (0% to 2%). Idiopathic NSIP occurs predominantly in middle-aged nonsmoking women; however, because of connective tissue diseases, NSIP affects men and women equally. The prognosis for NSIP varies. Some patients achieve improvement, while others remain stable despite therapy; sometimes the disease progresses to terminal fibrosis and death..
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