EFFECT OF CORONAVIRUS INFECTION ON THE EFFICACY OF ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

   Objective: To study the antihypertensive efficacy of 6-month combined therapy in patients with AH after coronavirus infection Material and methods: The study included patients with I-III degree of AH (ESC/ESH 2018), aged 30-75 years, both sexes, without severe comorbidities and cardiovascular complications (acute myocardial infarction, chronic heart failure, cerebrovascular diseases, cardiac arrhythmias, diabetes mellitus). All patients at the stage before treatment and 6-months of therapy were measured office BP by Korotkov's method, in order to study the daily profile of  BP (SPAD) we performed daily BP monitoring ("Registrator BR-102 plus" (SCHILLER, Switzerland)). Results: Carried COVID19 did not affect baseline office BP and DPBP(Daily profil blood pressure) scores. Nevertheless, the transferred coronovirus infection made a negative contribution to antihypertensive efficacy by the dynamics of DPBP indices. It should be noted that BP variability and nocturnal dipping of BP on the background of 6-month therapy improved only in the group of patients with AH COVID19(-).Conclusion: Thus, the results of our study demonstrated a negative course of AH after coronovirus infection. Despite the fact that coronovirus infection did not affect the positive dynamics of office BP parameters, significant improvement of the daily BP profile was observed only in COVID19(-) patients.