OVERWEIGHT, PRO-INFLAMMATORY STATUS AND DYNAMICS OF NTPROBNP IN LIVE RELATED KIDNEY TRANSPLANTATION DONORS AS MODIFYABLE FACTORS OF CARDIOVASCULAR RISK
Keywords:
NTproBNP, chronic kidney disease, body mass index, interleukins.Abstract
Optimal related kidney transplant donors were predominantly overweight, which correlated with the intensity of subclinical inflammation and endotoxemia. An increase in IL-6 and CRP in donors correlated with both age and BMI, proving the contribution of visceral fat depot to the implementation of subclinical inflammation. The age of the donor affected the levels of NTproBNP, SBP, DBP, IL-6, and CRP. Donor mothers had a statistically significantly elevated level of SMP and TNF-alpha, a significantly lower baseline GFR relative to the general group of donors. The level of GFR and NTproBNP in donors was within the reference interval before nephrectomy, however, GFR decreased statistically significantly, and NTproBNP increased by 24.2% on the 2nd day after nephrectomy both in the general group and in donors – mothers – by 27.5% from the initial and exceeding 125 pg/ml, reflecting adaptive responses after nephrectomy.
References
Бахритдинов Ф.Ш., Ахмедов А.Р., Абдугафуров З.У. Факторы риска дисфункции трансплантированной почки // Хирургия Узбекистан. – Ташкент, 2020, - №3. - С.37-43.
Готе С.В. Трансплантология 2008–2018: десят лет развития // Вестник трансплантологии и искусственных органов. - 2018. - №20(4). – С. 6-7.
Мацкевич С.А., К.С. Атрошенко, Белская М.И. Дисфункция почек при хронической сердечной недостаточности // Серцева недостатніст та коморбідні стани" № 3, груден 2017 р.
Маткаримов З.Т., Бахритдинов Ф.Ш., Ибадов Р.А., Суюмов А.С., Махмудов К.О., Ахмедов А.Р., Шерназаров Ш.И., Рустамов М.О., Абдугафуров З.У., Саатова У.М., Уринов Ж.Б. История и опыт трансплантации почки в Узбекистане // Вестник трансплантологии и искусственных органов.-2022.-Т. - № 1. – С. 23-30.
Мойсюк Я.Г., Сушков А.И., Шаршаткин А.В. Современные технологии и клинические исследования в трансплантации почки // Вестник трансплантологии и искусственных органов. - 2014. - Т. 16. - №3. - С. 6375.
Сапрыгин Д.Б., Мошина В.А. Клиническое значение определения мозгового натрийурического пептида (аминотерминалного фрагмента NT-proBNP) при кардиоваскулярной патологии // Лабораторная медицина.-2006.-№8.-С.213-225.
Akabayashi A. Twenty Years After Enactment of the Organ Transplant Law in Japan: Why Are There Still So Few Deceased Donors? // Transplantation Processing. – 2018. – V.50. - Is.5. - P. 1209-1219. DOI:10.1016/j.transproceed.2018.02.078.
Alehagen U., Dahlstrom U., Lindahl T.L. Cystatin C and NT-proBNP, a power¬ful combination of biomarkers for predicting cardiovascular mortality in elderly patients with heart failure: results from a 10-year study in primary care // Eur. J. Heart Fail. – 2009. – Vol. 11 (4). – P. 354-360.
Gruessner, R.W.G., Gruessner A.C. Solid-organ Transplants From Living Donors: Cumulative United States Experience on 140156 Living Donor Transplants Over Years// Transplantation Proceedings. – 2018. – Vol. 50 (10). – P. 3025-3035. DOI:1016/j. transproceed.2018.07.024.
Hillege Н., Van Gilst W., de Zeeuw D., van Veldhuisen D.J. Renal function as a predictor of prognosis in chronic heart failure // Heart Fail Monit. – 2002. – Vol. 2 (3). – P. 78-84.
Lo D.J., B. Kaplan, Kirk A.D. Biomarkers for kidney transplant rejection // Nature Reviews Nephrology. – 2014. – Vol. 10, № 4. – Р. 215.
Locke J.E. Obesity increases the risk of end-stage renal disease among living kidney donors // Kidney International. – 2017. - Vol.0000 91(3). – P. 699703. DOI: 10.1016/j.kint.2016.10.014.
Reese P.R., Boudville N., Garg A.X. Living kidney donation: outcomes, ethics, and uncertainty // The Lancet. – 2015. - Vol. 385 (9981). - P. 2003-2013 DOI: 10.1016/S0140-6736(14)62484-3.
Smilde T.D., Hillege H.L., Voors A.A. Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction // Am. J. Cardiol. – 2004. – Vol. 94 (2). – P. 240-243.
Steg PG et al. B-type natriuretic peptide and echocardiographic determination of ejection fraction in the diagnosis of congestive heart failure in patients with acute dyspnea // Chest 2005;128:21-9.
Strippoli G.F., Navaneethan S.D., Johnson D.W. Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials // BMJ. – 2008. – Vol. 336 (7645). –P. 645-651.
The consensus statement of the Amsterdam Forumon the care of the live kidney donor transplantation, 2004.
Weir M.R., Lerma E.V. Kidney Transplantation: Practical Guide to Management // Berlin: Springer Science & Business Media, 2014. — 438 p.
WHO, Lancet, 2004.-№363(9403):157-165).
