STATE OF THE IMMUNE SYSTEM AND THE DEVELOPMENT OF POST-TRANSFUSION COMPLICATIONS IN PATIENTS WITH HEMOPHILIA
Keywords:
hemophilia, cellular, humoral immunity, immunoreactivity.Abstract
The aim of the study is to study the immune status in patients with hemophilia. A complex of immunological studies aimed at determining individual populations and immunoregulatory subpopulations of lymphocytes was carried out in 45 patients with hemophilia, of which 25 suffered from a severe form and 20 were diagnosed with a moderate form of hemophilia. 16 practically healthy men were examined as a control group.
The results of studies show that hemophilia is accompanied by a violation of the immune status in patients, which manifests itself in changes in the cellular even (a sharp decrease in the total pool of T-lymphocytes and its subpopulation - TGF cells, with significantly high values of TGF cells) and humoral immunity (increase in the content of B- lymphocytes, severe dysimmunoglobulinemia with a decrease in the content of immunoglobulin A and an increase in the level of immunoglobulins M and G). The data of the FAN and CEC studies also confirm the fact of impaired immunoreactivity in patients with hemophilia: the FAN indicators are reduced, resulting in an increase in the CEC.
References
Волкова Л.И. Клинико-лабораторная характеристика смешанных и дефицитных форм гемофилии А, В и С у детей, проживающих на загрязненных радионуклидами территориях Республики Беларусь // Экологическая антропология: Материалы 9 междунар. науч.-практ. конф. «Экология человека в постчернобыльский период»: Минск, 2002. - С. 219-221.
Абдукадирова Н. Б., Раббимова Д. Т., Хаятова З. Б. The role of connective tissue dysplasias in pathology of various body systems //Journal of Siberian Medical Sciences. – 2020. – №. 3. – С. 126-135.
Shamsiyev A. M., Rabbimova D. T. Comprehensive approach to the problem of rehabilitation of infants submitted sepsis //Voprosy nauki i obrazovaniya. – 2017. – С. 152.
Шавази Н. и др. BOLALARDAGI BRONXO-OBSTRUKTIV SINDROMNI KOMPLEKS DAVOLASHDA NATRIY GIALURONAT PREPARATI BILAN INGALATSIYADAN FOYDALANISH SAMARADORLIGI //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 4. – С. 55-58.
Шавази Н. и др. BOLALARDA RETSIDIVLANUVCHI BRONXOOBSTRUKTIV SINDROM VA BRONXIAL ASTMANING EPIDEMIOLOGIK JIHATLARI //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 4. – С. 22-25.
Шавази Н. и др. СОВРЕМЕННЫЕ ВЗГЛЯДЫ ВОЗНИКНОВЕНИЯ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ У ДЕТЕЙ //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 1. – С. 40-43.
Турдибеков Х. и др. ИССЛЕДОВАНИЕ АССОЦИАЦИИ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНА β2-АДРЕНОРЕЦЕПТОРА С БРОНХИАЛЬНОЙ АСТМОЙ //Журнал кардиореспираторных исследований. – 2021. – Т. 2. – №. 4. – С. 41-44.
Meunier S, Menier C, Marcon E, Lacroix-Desmazes S, Maillere B. CD4 T cells specific for factor VIII are present at high frequency in healthy donors and comprise naïve and memory cells. blood advances. 2017;1(21):1842-1847.
Hamze M, Meunier S, Karle A, et al. Characterization of CD4 T cell epitopes of infliximab and rituximab identified from healthy donors. Front Immunol. 2017;8:500.
Hofbauer CJ, Whelan SF, Hirschler M, et al. Affinity of FVIII-specific antibodies reveals major differences between neutralizing and nonneutralizing antibodies in humans. Blood. 2015;125(7):1180–1188.
