CONTRIBUTION OF EPICARDIAL FAT DEPOSIT TO CYTOKINE PRODUCTION AND DEVELOPMENT OF HEMODYNAMICLY SIGNIFICANT CORONARY ARTERIAL STENOSE IN MATURE PERSONS
Keywords:
epicardial fat, adiponectin, tumor necrosis factor alpha, hemodynamically significant coronary artery stenosesAbstract
Evaluation of the significance of morphometric parameters of local fat depots of the heart and blood vessels in a cohort of patients with coronary artery disease, coupled with the measurement of the level of adipocytokines, can be useful in risk stratification for the development of hemodynamically significant stenoses of the coronary arteries. The purpose of the study: to study the relationship between indicators of adipokines status, the volume of visceral fat depots and the severity of coronary artery stenosis in adults. 135 patients (74 men and 61 women) with CAD and suspected CAD were studied. It was found that the volume of epicardial adipose tissue (EAT) of more than 109 ml in persons of mature age is associated with the development of hemodynamically significant stenosis (GDS) of the coronary arteries with a sensitivity of 81.2%, a specificity of 66.7% with an area under the characteristic curve AUC = 0.73. The development of hemodynamically significant stenoses of the coronary arteries is associated with a decrease in adiponectin less than 7.9 pg/ml, an increase in IL-6 more than 3.14 pg/ml, TNF-alpha - more than 3.52 pg/ml. In persons with hemodynamically significant stenoses, the volume of epicardial adipose tissue at the level of the middle third of the right coronary artery, the posterior wall of the right ventricle and the distal third of the anterior interventricular branch, as well as the area of epicardial adipose tissue, were significantly greater than in persons of mature age with hemodynamically insignificant stenoses (p <0.05).
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