METABOLIC SHIFTS AS AN INDICATOR OF POST-HYPOXIC COMPLICATIONS IN NEWBORNS

Abstract

The metabolic status was assessed in newborns full-term and with signs of prematurity in the early neonatal period with intrauterine hypoxia and acute asphyxia in history in order to identify possible dyselectrolytemia as a precursor of multiple organ changes at the preclinical stage of the disease.

Of the high-risk factors for intrauterine hypoxia, prolonged preeclampsia in pregnant women prevailed in 54% of mothers, anemia in 78%, the threat of miscarriage in 32%, cystitis, pyelonephritis, hepatitis, up to 24% of mothers.

Of the high-risk factors for acute asphyxia, operative delivery for various indications prevailed in up to 18% of mothers, oligohydramnios, or polyhydramnios in 18% of cases, a long anhydrous period in 12% of cases, the use of drugs and anesthesia before and during childbirth in 26% of mothers. A decrease in the level of phosphorus-calcium metabolism of magnesium, total protein, especially in full-term newborns, against the background of an increase in the level of alkaline phosphatase, has been identified.

Given the significant role of phosphorus in the myelination of nerve fibers and the participation of calcium and magnesium in the formation of latent neurological symptoms, the identified changes can be assessed as a risk factor for predisposition to a certain membrane pathology.

An increase in the level of alkaline phosphatase against the background of imperfection of protein metabolism reduces the intensity of plastic processes for a full-fledged energy metabolism.

In the absence of appropriate clinical symptoms, these laboratory phenomena serve as indicators of a certain pathological process at the preclinical stage.