EFFICIENCY OF ASPIRIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND CORONARY HEART DISEASE

Abstract

To study coagulation and intravenous platelet hemostasis when using aspirin in patients with rheumatoid arthritis (RA) in combination with coronary heart disease (CHD).               In our study, 82 patients (68 women and 14 men) were examined who were treated with RA in CHD.               Studies show that decreased fibrinogen and plasma fibrinolytic activity are associated with the development of atherosclerosis and an increased risk of heart attack and stroke. Our studies also reported similar changes in blood clotting despite the use of non-steroidal anti-inflammatory drugs (NSAID) and aspirin. In our study, resistance to NSAID, in particular to meloxicam, was 8.5%, to nimesulide 7.3% and to diclofenac 6%. Patients who did not show the antiplatelet effect of aspirin in combination with RA with coronary artery disease were prescribed another antiplatelet drug.