CLINICAL AND HEMODYNAMIC EFFICACY OF CHOLINE ALFOSCERATE IN ARTERIAL HYPERTENSION AND HYPERTENSIVE ENCEPHALOPATHY

Authors

  • Tulaboeva G.M
  • Talipova Yu.Sh
  • Abdukodirova N.M
  • Kamolov B.B
  • Saidov Kh.Kh

Keywords:

arterial hypertension, choline alfoscerate, hypertensive encephalopathy, cholinergic neurons

Abstract

This article presents data on the study of the clinical and hemodynamic efficacy of choline alfoscerate in arterial hypertension and hypertensive encephalopathy in patients with high cardiovascular risk. The results of the study showed a positive trend in terms of clinical and hemodynamic parameters. This is due to the fact that, as a result of improving the transmission of nerve impulses in cholinergic neurons, the plasticity of neuronal membranes increases and the structures of the reticular formation of the brain are activated. Gliatilin, due to its neuroprotective effect, improves cerebral blood flow, enhances metabolic processes in the brain and restores brain function in patients with a high cardiovascular risk of complications, with hypertensive encephalopathy.

References

Захаров В.В., Яхно Н.Н. Когнитивные расстройства в пожилом и старческом возрасте: Метод, пособие для врачей. М., 2005.

Румянцева Г.М. и др. // Качественная клиническая практика. 2002. № 1. С. 28.

Севастьянова Е.В., Повереннова И.Е. // Неврол. вестн. 2008. Т. XL. Вып. 1. С. 21.

Cerebrovascular Disease, Cognitive Impairment and Dementia /Ed. by J. O’Brien et al. L., 2004.

Cicconetti P. et al. // Clin. Exp. Hypertens. 2000. V. 22. P. 583.

Cherubini A. et al. // Am. J. Ther. 2007. V. 14. P. 533.

Di Bari M. et al. // Am. J. Epidemiol. 2001. V. 153. P. 72.

Forette F. et al. // Arch. Intern. Med. 2002. V. 162. P. 2046.

Morris J. et al. // Arch. Neurol. 2001. V. 58. P. 397.

McGuinness B. et al. // Cochrane Database Syst. Rev. 2006. V. 2.CD004034.

Muller W.E. et al. // Pharmacopsychiatry. 1999. V. 32. Suppl. 1. P. 2.

Published

2021-07-23