FEATURES OF COMPLICATED GENERALIZED TUBERCULOSIS

Authors

  • Pardayeva O‘g‘uloy Jamolovna
  • Isayeva Sohiba Chorievna
  • Ismailov Umidbek Kipchakbayevich
  • Berdiyorov Ulugbek Murodullaevich

Keywords:

Generalized tuberculosis, peritoneal adhesive disease, extrapulmonary tuberculosis, female genital tuberculosis

Abstract

The article describes a case involving a patient with a complicated course of generalized internal organ tuberculosis at the Samarkand Regional Ftiziatrics and Pulmonology Center.  Data from the analysis of the processing of primary documentation and a review of relevant literature are presented. The uncharacteristic clinical manifestation with a chronic course of the disease, the low level of vigilance of narrow specialists and general practitioners, served as a reason for the untimely diagnosis and disability of the patient, with the inability of the young organism to reproduce naturally.

In our case, generalized tuberculosis manifested as focal lesions of the lower lobe of the left lung and tuberculous lesions of the abdominal organs in the form of tuberculosis of the genital organs, visceral and parietal peritoneum, complicated by peritonitis and adhesions. FGenital tuberculosis in women is a chronic disease with mild symptoms. Often, the main cause of infertility in patients is a specific lesion of the endometrium and fallopian tubes.

Comprehensive treatment using antibacterial drugs yielded good results, with reversible development of specific abdominal organ inflammation and independent closure of the ileostomy.  In all manifestations of non-pulmonary tuberculosis, it is necessary to conduct a radiological examination of the lungs to detect lung damage.

References

Agrawal M., Roy P., Bhatia V., et al. Role of microbiological tests in diagnosis of genital tuberculosis of women with infertility: A view // Indian J. Tuberc. – 2019. – Vol. 66, № 2. – P. 234–239. – DOI: 10.1016/j.ijtb.2019.03.003.

Alemu A., Yesuf A., Gebrehanna E., et al. Incidence and predictors of extrapulmonary tuberculosis among people living with Human Immunodeficiency Virus in Addis Ababa, Ethiopia: A retrospective cohort study // PLoS One. – 2020. – Vol. 15, № 5. – e0232426. – DOI: 10.1371/journal.pone.0232426.

Bagchi B., Chatterjee S., Gon Chowdhury R. Role of latent female genital tuberculosis in recurrent early pregnancy loss: A retrospective analysis // Int. J. Reprod. Biomed. – 2019. – Vol. 17, № 12. – P. 929–934. – DOI: 10.18502/ijrm.v17i12.5799.

Djuwantono T., Permadi W., Septiani L., et al. Female genital tuberculosis and infertility: serial cases report in Bandung, Indonesia and literature review // BMC Res. Notes. – 2017. – Vol. 10, № 1. – P. 683. – DOI: 10.1186/s13104-017-3057-z.

Efared B., Sidibé I.S., Erregad F., et al. Female genital tuberculosis: a clinicopathological report of 13 cases // J. Surg. Case Rep. – 2019. – Vol. 2019, № 3. – rjz083. – DOI: 10.1093/jscr/rjz083.

Feng Q., Hu X., Zhao J., et al. Female genital tuberculosis presented with primary infertility and persistent CA-125 elevation: A case report // Ann. Med. Surg. (Lond). – 2022. – Vol. 78. – 103683. – DOI: 10.1016/j.amsu.2022.103683.

Gupta S., Gupta P. Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors // Front. Immunol. – 2020. – Vol. 11. – 02161. – DOI: 10.3389/fimmu.2020.0216.

Iyer V.K., Malhotra N., Singh U.B., et al. Immunohistochemical evaluation of infiltrating immune cells in endometrial biopsy of female genital tuberculosis // Eur. J. Obstet. Gynecol. Reprod. Biol. – 2021. – Vol. 267. – P. 174–178. – DOI: 10.1016/j.ejogrb.2021.10.031.

Kulchavenya E., Kholtobin D., Shevchenko S. Challenges in urogenital tuberculosis // World J. Urol. – 2020. – Vol. 38, № 1. – P. 89–94. – DOI: 10.1007/s00345-019-02767-x.

Naik S.N., Chandanwale A., Kadam D., et al. Detection of genital tuberculosis among women with infertility using best clinical practices in India: An implementation study // Indian J. Tuberc. – 2021. – Vol. 68, № 1. – P. 85–91. – DOI: 10.1016/j.ijtb.2020.08.003.

Published

2025-06-10