MECHANISMS OF FORMATION OF HEART DYSFUNCTION AND THE APPLICATION OF SAKUBUTRI/VALSARTAN IN DIABETES MELLITUS
Keywords:
heart failure, diabetes mellitus, ejection fraction, sacubitril/valsartanAbstract
The incidence of diabetes mellitus (DM) in patients with heart failure (HF) is about 40%, regardless of the level of ejection fraction (EF) impairment. But, in addition, diabetes is considered a strong independent risk factor for the progression of heart failure with both preserved and reduced EF and is usually associated with a poor prognosis. The ability of neprilisin inhibitors to increase levels of biologically active natriuretic peptides has made them a potential therapeutic approach in the treatment of HF. The use of sacubitril/valsartan in patients with heart failure with diabetes continues to be studied.
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