COVID-19DAN SO’NG TUXUMDONLARNING MUDDATIDAN ILGARI YETISHMOVCHILIGI RIVOJLANISHIDA KISS1 VА BDNF TA’SIRI
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tuxumdonlarning muddatidan ilgari yetishmovchili, KOVID-19, stress, KISS1, DBNF##article.abstract##
Bugungi kunda tuxumdonlarning muddatidan ilgari yetishmovchiligi (TMIY) ayollar salomatligining eng qiyin muammolaridan biridir.
Dolzarblik. Ayollarda bepushtlik va hayot sifatining pasayishi asosiy sababi bo'lgan TMIY alohida e'tibor talab qiladigan muammodir. Tasdiqlangan tashxisdan so'ng, hozirgi vaqtda tuxumdonlar faoliyatini va fertillikni tiklash usullari mavjud emas. COVID-19 virusining tarqalishi va pandemiya bilan bogʻliq karantin choralari ayollarning ruhiy salomatligi va hayz koʻrish davrining buzilishiga, jumladan, amenoreyagacha olib keldi. Shuning uchun TMIY rivojlanishining erta bosqichda xavf omillarini aniqlash muhimdir.
Maqsad. Koronavirus infeksiyasidan keyin rivojlangan TMIY bo'lgan bemorlarda KISS1 va BDNFning plazma kontsentratsiyasini baholash.
Materiallar va usullar. COVID-19dan so’ng TMIY bilan kasallangan 52 bemor ayollar va hayz sikli muntazam bo’lgan 18 yoshdan 40 yoshgacha bo'lgan 32 sog'lom ayol o'rtasida so'rov o'tkazildi. RIEIATM laboratoriyasida kisspeptin (HUMAN KISS1) va BDNF (HUMAN BDNF)ning qondagi kontsentratsiyasi Human Elisa Kit yordamida o'rganildi. Statistik tahlil Minitab 14 dasturi yordamida amalga oshirildi.
Natijalar. Koronavirus infeksiyasidan so'ng TMIY rivojlangan ayyollarda KISS1 darajasi sezilarli darajada past (251,70±7,27 pg/ml, p<0,05), sog'lom ayollarda esa ularga nisbatan yuqori edi (439,91 ± 8,41 pg / ml, p< 0,05). BDNF kontsentratsiyasi ham birinchi guruhda (232,82±7,29 pg/ml, p<0,05) sog'lom ayollarga (428,59±7,22 pg/ml, p<0,05) nisbatan past edi. KISS1 va BDNFning sqondagi miqdori stress darajasi bilan salbiy korrelyatsiya aniqlandi.
Xulosa. Xulosa qilib aytish mumkinki, kisspeptin va BDNF nafaqat ayollarning reproduktiv salomatligi, balki ruhiy holatida ham muhim rol o'ynaydi. Koronavirus pandemiyasi tufayli yuzaga kelgan stress, qondagi KISS1 va BDNF darajasini pasaytirishi tuxumdonlarning muddatidan ilgari yetishmovchili rivojlanishiga olib kelishi mumkin. Ushbu kuzatish TMIY patogenezida muhim potentsial tushuncha beradi.
Библиографические ссылки
Abu Helwa HA, Mitaeb AA, Al-Hamshri S, Sweileh WM. Prevalence of dysmenorrhea and predictors of its pain intensity among Palestinian female university students. BMC Womens Health (2018) 18(1):18. doi: 10.1186/s12905-018-0516-1
Beck-Peccoz P, Persani L. Premature ovarian failure. Orphanet J Rare Dis. 2006;1:9.
Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol. 1986;67(4):604–6.
Ferreira, R.; Oliveira, J.F.; Fernandes, R.; Moraes, J.F.; Bayard, G.P. The role of angiotensin II in the early stages of bovine ovulation. Reproduction 2007, 134, 713–719.
Gunning M.N., Troìa L., Janse F.J. et al. Premature ovarian insufficiency. Female Reprod Dysfunct. 2020:287–307.
Jungari SB, Chauhan BG. Prevalence and determinants of premature menopause among indian women: issues and challenges ahead. Health Soc Work. 2017;42(2):79–86.
Luborsky JL, Meyer P, Sowers MF, et al. Premature menopause in a multi-ethnic population study of the menopause transition. Hum Reprod 2003; 18: 199-206.
Management of women with premature ovarian insufficiency. Guideline of the European Society of Human Reproduction and Embryology [Electronic resource]. – 2015. https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Management-of-premature-ovarian- insufficiency.aspx
Meng,W.; Lingwei, M.; Xue, L.; Zhu, Q.; Zhou, S.; Dai, J.; Yan,W.; Zhang, J.;Wang, S. Co- expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age. Genomics 2021, 113, 3449–3460.
Podfigurna-Stopa, A. Premature ovarian insufficiency: the context of long-term effects / A. Podfigurna-Stopa, A. Czyzyk, M. Grymowicz [et al.] // J.Endocrinol. Invest. – 2016. – Vol. 39,
№9. – P. 983-990
Progetto Menopausa Italia Study G. Premature ovarian failure: frequency and risk factors among women attending a network of menopause clin ics in Italy. BJOG 2003; 110(1):59–63.
Shuttleworth, G.; Broughton Pipkin, F.; HunteIn, M.G. In vitro development of pig preantral follicles cultured in a serum-free medium and the effect of angiotensin II. Reproduction 2002, 123, 807–818.
Vaz-Silva J, Carneiro MM, Ferreira MC, Pinheiro SVB, Silva DA, Silva AL, Witz CA, Reis AM, Santos RA, Reis FM (2009) The vasoactive peptide angiotensin- (1—7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reprod Sci 16:247–256
The ESHRE Guideline Group on POI, L. Webber, M. Davies, R. Anderson, J. Bartlett, D. Braat,
B. Cartwright, R. Cifkova, S. de Muinck Keizer-Schrama, E. Hogervorst, F. Janse, L. Liao, V. Vlaisavljevic, C. Zillikens, N. Vermeulen, ESHRE Guideline: management of women with premature ovarian insufficiency, Human Reproduction, Volume 31, Issue 5, May 2016, Pages 926–937, https://doi.org/10.1093/humrep/dew027
Williams NI, Berga SL, Cameron JL. Synergism between psychosocial and metabolic stressors: impact on reproductive function in cynomolgus monkeys. Am J Physiol Endocrinol Metab (2007) 293(1):E270–6. doi: 10.1152/ajpendo.00108.200
Блинов Д. В., Хазан П. Л., Мнацаканьян А. Н., Корабельников Д. И., Сафаров А. Т., Павлова Н. В., Захарова Н. С., Пономарев Д. А., Петренко Д. А. Ранняя менопауза и преждевременная недостаточность яичников: проблемы и перспективы. Акушерство, Гинекология и Репродукция. 2020;14(3):328–345. https://doi.org/10.17749/2313- 7347/ob.gyn.rep.2020.173.
Гальцев Е.В., Казенашев В.В. Психосоциальный дискомфорт у женщин с урогенитальными расстройствами. Акушерство, Гинекология и Репродукция. 2007;(2):4–9.
Новикова В.А., Федорович О.А., Атанесян Э.Г. Комплексная терапия атрофии урогенитального тракта у женщин пременопаузального периода с преждевременной недостаточностью функции яичников. Акушерство, Гинекология и Репродукция. 2008;(7):14–6.
Табеева, Г.И. Преждевременная недостаточность яичников – загадка ХХ века / Г.И. Табеева, Н.Н. Шамилова, Н.А.Жахур и др. // Акушерство и гинекология. – 2013. - №12.
– С. 16-21.
Фахрутдинова С.С., Роль клинико-генетических маркеров в прогнозировании преждевременной недостаточности яичников: автореф. дисс. PhD, Ташкент., 2019. – 97с.
Чеботникова, Т.В. Преждевременная недостаточность яичников: мнение экспортов / Т.В. Чеботникова // Вестник репродуктивного здоровья. – 2007. - №1. – С. 22-32.
