INFLUENCE OF KISS1 AND BDNF ON THE DEVELOPMENT OF PREMATURE OVARIAN INSUFFICIENCY AFTER COVID-19
Keywords:
premature ovarian insufficiency, COVID-19, stress, KISS1, BDNFAbstract
Today, premature ovarian failure (POF) is one of the most difficult problems of women's health.
Relevance. As the main cause of infertility, a decrease in the quality of life of women with POI is a problem that needs special attention. After a confirmed diagnosis, there are currently no methods to restore ovarian function and fertility. The spread of the COVID-19 virus and pandemic-related quarantine measures have led to women's mental health and menstrual irregularities, up to and including amenorrhea. Therefore, it is important to identify risk factors for the development of POI at an earlier stage.
Purpose. To evaluate the plasma concentration of KISS1 and BDNF in patients with POI that developed after coronavirus infection.
Materials and methods. A survey of 52 patients with POI, after undergoing COVID-19 and 32 healthy women, aged 18 to 40 years with a regular menstrual cycle, was carried out. The blood concentrations of kisspeptin (HUMAN KISS1) and BDNF (Human BDNF) were studied using the Human Elisa Kit in the laboratory of RSSPMCE. Statistical analysis was performed using Minitab 14.
Results. In women with POI, developed after coronavirus infection the level of KISS1 was significantly lower (251.70±7.27 pg/ml, p<0.05) than in healthy women (439.91±8.41 pg/ml, p< 0.05). The BDNF concentration was also lower in the first group (232.82±7.29 pg/ml, p<0.05) than in healthy women (428.59±7.22 pg/ml, p<0.05). Serum levels of KISS1 and BDNF are negatively correlated with stress severity.
Conclusion. We can say that kisspeptin and BDNF play an important role not only in women's reproductive health, but also in their mental state. Stress due to the coronavirus pandemic, reducing the level of KISS1 and BDNF in the blood can lead to the development of premature ovarian failure. This observation brings important potential insight into the pathogenesis of POI.
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