COVID-19 INFEKTSIYASIDAN KEYIN RIVOJLANGAN QANDLI DIABET 1TURI TADQIQOTI: ENDOTELIAL DISFUNKTSIYASI VA OTOIMMÜN KASALLIKMI?
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post-COVID-19, endoteliya disfunktsiyasi, ICAM-1, VCAM-1, diabetga xos antitanachalar##article.abstract##
Dolzarblik. Endoteliya funksiyasining buzilishi qandli diabet (insult, infarkt) bilan og‘rigan bemorlarda makrososudli asoratlarning rivojlanishida, shuningdek, mikrososudli diabetik asoratlarning rivojlanishida yetakchi o‘rinlardan birini egallaydi. Maqsad: COVID-19 infektsiyasini o'tkazib yuborganidan keyin yuzaga kelgan qandli diabet 1 turining xususiyatlarini o‘rganish. Materiallar va usullar: 70 bemorda gemostaz parametrlar, D vitamini darajasi va oshqozon osti bezi beta hujayralariga xos autotanachalar tekshirildi. Natijalar: Bizning kesishgan tadqiqotimizda COVID-19 dan keyin qandli diabet 1 tur (16,7%) va LADA (4,76%) bilan kasallanishning nisbatan yuqori ekanligini aniqladik. Qandli diabet 1 turiga chalingan kattalar asosan ayollar bo‘lib, oilada qandli diabetga moyillik darajasi yuqori edi. Qandli diabet 1 turiga chalingan bemorlarning ko‘pchiligi COVID-19 ni engil o‘tkazgan va COVID-19 ning o'tkir davrida kortikosteroidlar ishlatmagan. Og‘ir yoki engil COVID-19 bilan og‘rigan bemorlar ham diabet rivojlanishi xavfi ostida edi. Yangi aniqlangan qandli diabet bilan og‘rigan barcha bemorlarda D vitamini darajasi past bo‘lgan, ammo O‘zbekistonda yaxshi insolyatsiya mavjudligi ma'lum. Yangi aniqlangan diabet COVID-19 infektsiyasidan keyin 0 oydan 24 oygacha bo‘lgan vaqt ichida qayd etildi. Xulosa: COVID-19 dan keyin qandli diabetga xos ijobiy antitanachalar bilan qandli diabet 1 turining ko‘payishi SARS-CoV-2 tomonidan oshqozon osti bezi orolchalari hujayralari va ularning tarkibiy qismlariga zarar yetkazilishiga va shu bilan birga autoimmun mexanizmlarining faollashishiga dalolat qiladi. COVID-19 dan keyin qandli diabet tashxisi qo‘yilgan oilaviy qandli diabeti bo‘lgan yosh ayollar kasallik turini to‘g‘ri ajratish va insulin bilan o‘z vaqtida davolash uchun qandli diabetga xos antitanachalar tekshiruvini o‘tqazishlari kerak. COVID-19 dan keyin rivojlanadigan 1-tur diabetni yurak-qon tomir kasalliklari va endoteliya disfunktsiyasi bilan bog‘liq kasallik deb hisoblash kerak.
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