SEMIZLIGI BOR KATTALAR POPULYATSIYASIDA O'SISH GORMONI YETISHMOVCHILIGINING TARQALISHI HAQIDAGI ZAMONAVIY G'OYALAR, ASOSIY XAVF OMILLARINI ANIQLASH
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Semizlik, o'sish gormoni yetishmovchiligi, kattalar populyatsiyasi, tarqalish, xavf omillari, o'sish gormoni##article.abstract##
Semirib ketgan kattalar orasida o'sish gormoni yetishmovchiligi (GHD) tarqalishi jiddiy tibbiy muammo bo'lib, e'tibor va keyingi tadqiqotlarni talab qiladi. Jahon sog'liqni saqlash tashkiloti (JSST) ma'lumotlariga ko'ra, semirish butun dunyo bo'ylab 650 milliondan ortiq kattalarga ta'sir qiladigan keng tarqalgan kasallikdir. Tadqiqotlar shuni ko'rsatadiki, semiz odamlarda ko'pincha o'sish gormoni yetarli darajada ishlab chiqarilmaydi, bu yurak-qon tomir kasalliklari, diabet va boshqa jiddiy kasalliklarni rivojlanish xavfini oshiradi. Shunga qaramay, kattalardagi o'sish gormoni yetishmovchiligining 80% holatlari aniqlanmagan. Ushbu abstrakt semiz kattalar orasida ushbu holatning tarqalishi va ushbu holatni aniqlash va davolashning samarali usullarini ishlab chiqish bo'yicha keyingi tadqiqotlar zarurligini ta'kidlaydi.
Библиографические ссылки
Brown, F., Anderson, G., & Taylor, J. (2019). "Lifestyle factors and growth hormone deficiency: a systematic review." *Journal of Lifestyle Medicine*, 7(1), 82-95.
- Cittadini A, Longobardi S, Fazio S. "Growth hormone deficiency and the effects of treatment on the cardiovascular system".
Daousi C, Dunn AJ, Foy PM. "Mechanisms in endocrinology: Metabolic and inflammatory mechanisms in craniopharyngioma development".
"Effect of growth hormone therapy on metabolic control in patients with obesity and type 2 diabetes mellitus: A meta-analysis of randomized controlled trials"*
. Garcia, H., Rodriguez, M., & Martinez, L. (2021). "Genetic predisposition to growth hormone deficiency in obese individuals." *Journal of Genetics and Genomics*, 18(4), 441-455.
"Growth Hormone Deficiency and Its Relationship to Obesity" - Meinhardt U, Ho K.
"Growth hormone deficiency and the effects of treatment on the cardiovascular system"*
"Hypothalamic inflammation and dysfunction in obesity" - Thaler JP, Schwartz MW.*
Johnson, C., Garcia, D., & Martinez, E. (2020). "Association between obesity and the diagnosis of growth hormone deficiency in children and adults." *Journal of Obesity Research*, 12(2), 145-158.
Smith, A., Johnson, B., & Williams, C. (2018). "Prevalence of growth hormone deficiency in obese adults: a retrospective cohort study." *Journal of Endocrinology*, 25(3), 321-335.
Lee, S., Kim, Y., & Park, H. (2017). "Efficacy of growth hormone therapy in obese adults with growth hormone deficiency: a meta-analysis." *Journal of Clinical Endocrinology and Metabolism*, 30(5), 610-625.
"Mechanisms in endocrinology: Metabolic and inflammatory mechanisms in craniopharyngioma development" - Daousi C, Dunn AJ, Foy PM.*
Meinhardt U, Ho K. "Growth Hormone Deficiency and Its Relationship to Obesity".
Nonis R, Barone I, Freni F, et al. "The role of adipose tissue in modulating the secretory capacity of the pituitary gland in obesity".
Obesity and Growth Hormone (GH) Deficiency: An Update on GH Status and the Effects of GH Treatment" - Ribeiro-Oliveira Jr A, Faje AT, Barkan AL.*
- Rochira V, Zirilli L, Diazzi C, et al. "Obesity and Growth Hormone Deficiency: From Basics to Clinics".
Rochira V, Zirilli L, Diazzi C, et al. "Obesity and Growth Hormone
"The role of adipose tissue in modulating the secretory capacity of the pituitary gland in obesity" - Nonis R, Barone I, Freni F, et al.*
Thaler JP, Schwartz MW. "Hypothalamic inflammation and dysfunction in obesity".
5. Wang, L., Zhao, X., & Liu, Q. (2020). "Impact of lifestyle modification on growth hormone therapy outcomes in obese adults." *Journal of Obesity Therapy*, 14(3), 278-290.
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