MODERN IDEAS ABOUT THE PREVALENCE OF GROWTH HORMONE DEFICIENCY AMONG THE ADULT POPULATION IN OBESE INDIVIDUALS, IDENTIFICATION OF THE MAIN RISK FACTORS

Authors

  • Kholikova Adliya Omonullaevna
  • Rakhimova Aziza Rakhmon kizi

Keywords:

Obesity, Growth hormone deficiency, adult population, prevalence, risk factors, growth hormone

Abstract

The prevalence of growth hormone deficiency (GHD) among obese adults is a serious medical problem that requires attention and further research. According to the World Health Organization (WHO), obesity is a widespread disease affecting more than 650 million adults worldwide. Research shows that obese people often have insufficient production of growth hormone, which can increase the risk of developing cardiovascular disease, diabetes and other serious diseases. Despite this, up to 80% of cases of growth hormone deficiency in adults remain undiagnosed. This abstract highlights the need for further research into the prevalence of this condition among obese adults and the development of effective methods for identifying and treating this condition.

References

Brown, F., Anderson, G., & Taylor, J. (2019). "Lifestyle factors and growth hormone deficiency: a systematic review." *Journal of Lifestyle Medicine*, 7(1), 82-95.

- Cittadini A, Longobardi S, Fazio S. "Growth hormone deficiency and the effects of treatment on the cardiovascular system".

Daousi C, Dunn AJ, Foy PM. "Mechanisms in endocrinology: Metabolic and inflammatory mechanisms in craniopharyngioma development".

"Effect of growth hormone therapy on metabolic control in patients with obesity and type 2 diabetes mellitus: A meta-analysis of randomized controlled trials"*

. Garcia, H., Rodriguez, M., & Martinez, L. (2021). "Genetic predisposition to growth hormone deficiency in obese individuals." *Journal of Genetics and Genomics*, 18(4), 441-455.

"Growth Hormone Deficiency and Its Relationship to Obesity" - Meinhardt U, Ho K.

"Growth hormone deficiency and the effects of treatment on the cardiovascular system"*

"Hypothalamic inflammation and dysfunction in obesity" - Thaler JP, Schwartz MW.*

Johnson, C., Garcia, D., & Martinez, E. (2020). "Association between obesity and the diagnosis of growth hormone deficiency in children and adults." *Journal of Obesity Research*, 12(2), 145-158.

Smith, A., Johnson, B., & Williams, C. (2018). "Prevalence of growth hormone deficiency in obese adults: a retrospective cohort study." *Journal of Endocrinology*, 25(3), 321-335.

Lee, S., Kim, Y., & Park, H. (2017). "Efficacy of growth hormone therapy in obese adults with growth hormone deficiency: a meta-analysis." *Journal of Clinical Endocrinology and Metabolism*, 30(5), 610-625.

"Mechanisms in endocrinology: Metabolic and inflammatory mechanisms in craniopharyngioma development" - Daousi C, Dunn AJ, Foy PM.*

Meinhardt U, Ho K. "Growth Hormone Deficiency and Its Relationship to Obesity".

Nonis R, Barone I, Freni F, et al. "The role of adipose tissue in modulating the secretory capacity of the pituitary gland in obesity".

Obesity and Growth Hormone (GH) Deficiency: An Update on GH Status and the Effects of GH Treatment" - Ribeiro-Oliveira Jr A, Faje AT, Barkan AL.*

- Rochira V, Zirilli L, Diazzi C, et al. "Obesity and Growth Hormone Deficiency: From Basics to Clinics".

Rochira V, Zirilli L, Diazzi C, et al. "Obesity and Growth Hormone

"The role of adipose tissue in modulating the secretory capacity of the pituitary gland in obesity" - Nonis R, Barone I, Freni F, et al.*

Thaler JP, Schwartz MW. "Hypothalamic inflammation and dysfunction in obesity".

5. Wang, L., Zhao, X., & Liu, Q. (2020). "Impact of lifestyle modification on growth hormone therapy outcomes in obese adults." *Journal of Obesity Therapy*, 14(3), 278-290.

World Health Organization

Published

2024-11-06