SOMATIK VA STOMATOLOGIK KASALLIKLAR VAQTIDA ORGANIZMDA D VITAMINI SINTEZINING PATOGENETIK ROLI
##article.subject##:
vitamin D deficiency, osseointegration, dental implants, regeneration, periodontium, caries.##article.abstract##
D vitamini tanqisligi, odatda, quyosh nuriga etarlicha ta'sir o'tkazmaslik va / yoki yosh bilan terining sintetik xususiyatlarining pasayishi tufayli organizmda vitaminning etarli darajada sintez qilinmasligi tufayli yuzaga keladi. Doimiy, og'ir D vitamini etishmovchiligi bolalarda raxit yoki kattalardagi osteomalaziya klinik ko'rinishi bilan suyak demineralizatsiyasiga olib keladi. Suyaklarga ta'sir qilishdan tashqari, D vitaminining past darajasi ko'plab ekstraosseous ta'sirlar bilan bog'liqligi haqida keng ko'lamli eksperimental va epidemiologik dalillar mavjud. Insulin retseptorlari va insulin sekretsiyasini tartibga solishda D vitaminining roli eksperimental ravishda isbotlangan va markaziy asab, endokrin va immun tizimlariga, shuningdek, hujayralar differentsiatsiyasi va o'sishiga ijobiy ta'sir ko'rsatgan. D vitaminining yurak-qon tomir va nafas olish tizimlariga ijobiy ta'siri ko'p jihatdan bahsli bo'lib qolmoqda. Periodontitning og'irligi va 25(OH) D vitaminining past darajasi o'rtasidagi bog'liqlik isbotlangan.Bu D vitaminining past darajasi va periodontal kasalliklar patogenezi va uning rivojlanishi o'rtasidagi bog'liqlikdan dalolat beradi. D-gipovitaminozi dental implantlarning yo'qolishiga olib kelishi mumkin. D vitamini tanqisligi va kasallikning rivojlanishiga qarshi turish uchun D vitamini etishmovchiligi xavfi yuqori bo'lgan bemorlarga D vitamini holatini aniqlash va test natijalariga ko'ra, ayniqsa, quyosh nuri kam bo'lgan oylarda profilaktik D vitamini qo'shimchalarini olish tavsiya etiladi
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Бекжанова Ольга Есеневна- д.м.н., профессор, Заведующая кафедрой факультетской терапевтической стоматологии, Ташкентский государственный стоматологический институт, Ташкент, Узбекистан. Е-mail: olga.bekjanova@gmail.com, https://orcid.org/ 0000-0002-1686-1820
Маннанов Жавлонбек Жамолиддинович- Старший преподаватель кафедры ирургической стоматологии и дентальной имплантологии, Ташкентский государственный стоматологический институт, Ташкент, Узбекистан. Е-mail: dr.javlonbek77@gmail.com, https://orcid.org/ 0009-0008-7395-8734
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Бекжанова О.Е. — идеологическая концепция работы, написание текста; редактирование статьи;
Мананов Ж.Ж. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Bekjhanova Olga Esenovna - DSc, Professor, Head of the Department of Faculty Therapeutic Dentistry, Tashkent State Dental Institute, Tashkent, Uzbekistan. E-mail: olga.bekjanova@gmail.com , https://orcid.org / 0000-0002-1686-1820
Mannanov Javlonbek Jamoliddinovich Senior lecturer at the Department of Surgical Dentistry and Dental Implantology, Tashkent State Dental Institute, Tashkent, Uzbekistan. E-mail: dr.javlonbek77@gmail.com, https://orcid.org / 0009-0008-7395-8734
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Bekjanova OE — ideological concept of the work, writing the text; editing the article;
Mananov JJ — collection and analysis of literature sources, writing the text.
