TUXUMDONLARI MUDDATIDAN OLDIN SO‘NGAN AYOLLARDA REPRODUKTIV FAOLIYATNI TIKLASHNING ZAMONAVIY USULLARI SAMARADORLIGI
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tuxumdonlarning muddatidan oldin yetishmovchiligi, ovaryal zaxira, antimyuller gormoni, follikulostimullovchi gormon, reproduktiv funksiya, bepushtlik, diagnostika, davolash##article.abstract##
Tadqiqot maqsadi. Tuxumdonlarning muddatidan oldin yetishmovchiligi bo‘lgan ayollarda reproduktiv funksiyani tiklashning zamonaviy usullari samaradorligini ovaryal zaxirani kompleks klinik-laborator baholash hamda reproduktiv natijalarni tahlil qilish asosida baholash. Tadqiqot materiallari va usullari. Tadqiqot 2021–2025-yillarda Samarqand davlat tibbiyot universiteti bazasida o‘tkazildi. Tadqiqotga reproduktiv yoshdagi 120 nafar ayol jalb qilindi. Asosiy guruhni tuxumdonlarning muddatidan oldin yetishmovchiligi tashxisi qo‘yilgan 70 nafar bemor, nazorat guruhini esa tuxumdon funksiyasi saqlangan tubar-peritoneal bepushtligi bo‘lgan 50 nafar ayol tashkil etdi. Barcha ishtirokchilarda klinik tekshiruv, reproduktiv anamnezni baholash, follikulostimullovchi gormon (FSH), lyuteinlashtiruvchi gormon (LH), estradiol va antimyuller gormoni (AMH) darajalari aniqlandi. Shuningdek, transvaginal ultratovush tekshiruvi yordamida antral follikulalar soni hisoblanib, ovaryal zaxira baholandi. Davolash samaradorligi klinik holat, gormonal ko‘rsatkichlar hamda reproduktiv natijalar dinamikasi asosida tahlil qilindi. Natijalar. Tuxumdonlarning muddatidan oldin yetishmovchiligi bo‘lgan bemorlarda nazorat guruhiga nisbatan ovaryal zaxiraning sezilarli darajada pasaygani kuzatildi. Bu holat follikulostimullovchi gormon darajasining oshishi, antimyuller gormoni miqdorining kamayishi hamda antral follikulalar sonining qisqarishi bilan namoyon bo‘ldi. Zamonaviy kompleks davolash usullarini qo‘llash natijasida gormonal ko‘rsatkichlarda ijobiy o‘zgarishlar, tuxumdonlarning funksional faolligi yaxshilanishi va ovulyatsiyaning tiklanish ehtimoli ortishi kuzatildi. Olingan natijalar ushbu toifadagi bemorlarni davolashda zamonaviy reproduktiv va regenerativ texnologiyalarni o‘z ichiga olgan individual yondashuvning istiqbolli ekanligini ko‘rsatdi. Xulosa. Tuxumdonlarning muddatidan oldin yetishmovchiligi bo‘lgan ayollarda reproduktiv funksiyani tiklashga qaratilgan zamonaviy diagnostik va davolash usullarini kompleks qo‘llash tuxumdonlarning funksional holatini yaxshilash, davolash samaradorligini oshirish hamda reproduktiv salohiyatni ro‘yobga chiqarish imkoniyatlarini kengaytiradi. Bemorlarni individual yondashuv asosida olib borish davolash taktikasini optimallashtirish va homiladorlikka erishish ehtimolini oshirish imkonini beradi.
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