SINTETIK KATINONLARNING SUITSIDAL XULQ-ATVORGA TA’SIRI: QARAMLIKKA EGA BEMORLARNING RETROSPEKTIV TAHLILI
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sintetik katinonlar, Alfa-PVP, suitsidal xulq-atvor, yangi psixoaktiv moddalar, moddalar iste’moli buzilishlari.##article.abstract##
Sintetik katinonlar (SK) yangi psixoaktiv moddalarning (YPM) muhim sinfi bo‘lib, noqonuniy giyohvand moddalar bozorida tobora keng tarqalmoqda. Ularning keng mavjudligi va shartli ravishda “qonuniy” deb qabul qilinishi, jiddiy psixiatrik asoratlar mavjudligiga qaramay, iste’mol darajasining oshishiga olib kelmoqda. Shu jumladan, suitsidal xulq-atvor muhim muammo bo‘lib qolmoqda. Biroq SK iste’moli va suitsidal xulq-atvor o‘rtasidagi bog‘liqlik yetarlicha o‘rganilmagan. Ushbu tadqiqot SK iste’moli va suitsid xavfi o‘rtasidagi bog‘liqlikni aniqlashga qaratilgan.
Usullar. 2022–2024 yillarda O‘zbekiston Respublikasidagi Respublika ixtisoslashtirilgan ruhiy salomatlik ilmiy-amaliy tibbiyot markazida retrospektiv kohort kuzatuv tadqiqoti o‘tkazildi. Moddalar iste’moli buzilishlari tashxisi qo‘yilgan jami 138 bemor ikki guruhga ajratildi: asosiy guruh (n = 98) — sintetik katinonlarga qaram bemorlar (ICD-10 kodi F15.2); taqqoslash guruhi (n = 40) — boshqa psixostimulyatorlarga qaram bemorlar. Ma’lumotlar klinik hujjatlar, strukturaviy intervyular va standartlashtirilgan so‘rovnomalar, jumladan C-SSRS yordamida yig‘ildi. SC va suitsid xavfi o‘rtasidagi bog‘liqlik OR, RR va NNT orqali baholandi.
Natijalar. Alfa-PVP iste’moli va suitsidal xavf oshishi o‘rtasida ishonchli bog‘liqlik aniqlandi (OR = 2.76; 95% CI: 1.19–6.39; p = 0.026; RR = 2.07; 95% CI: 1.09–3.95; p = 0.026). NNT (4.97) ko‘rsatkichiga ko‘ra, har 5 nafar Alfa-PVP iste’molchidan bittasida qo‘shimcha yuqori suitsidal holat kuzatiladi.
Xulosa. Alfa-PVP yuqori suitsidal xavf bilan bog‘liq bo‘lgan modda sifatida alohida e’tibor talab qiladi va klinik monitoringni kuchaytirishni talab etadi. Natijalarni tasdiqlash uchun qo‘shimcha prospektiv tadqiqotlar zarur.
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