O'TKIR REVMATIK ISITMA BO'LGAN BOLALARDA YALLIG'LANISH FAOLIYATINING PREDIKTORI SIFATIDA D VITAMINI YETISHMAYDIGANLIGINI BAHOLASH
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o'tkir revmatik isitma, D vitamini yetishmovchiligi, IL-6, sitokinlar, bolalar, yallig'lanish, immun javob##article.abstract##
O'tkir revmatik isitma rivojlanayotgan mamlakatlarda bolalar salomatligining muhim muammosi bo'lib qolmoqda. So'nggi tadqiqotlar shuni ko'rsatadiki, D vitamini yallig'lanish kasalliklarida muhim immunomodulyator rol o'ynaydi.
Maqsad: O'tkir revmatik isitma bilan og'rigan bolalarda D vitamini yetishmasligi va yallig'lanish sitokinlari (IL-1β, IL-6, IL-8, IFN-γ) o'rtasidagi bog'liqlikni o'rganish.
Usullar: Tadqiqotda ARF tashxisi qo'yilgan 5-15 yoshli 60 bola ishtirok etdi. Ushbu tadqiqotning bir qismi sifatida, o'tkir revmatik isitma bilan og'rigan bolalarda 25(OH)D konsentratsiyasi baholandi va shu yoshdagi sog'lom bolalarning ma'lumotlari bilan taqqoslandi. Davolashdan oldin va keyin 25(OH)D va yallig'lanishga qarshi sitokinlarning zardobdagi darajasi o'lchandi. D vitamini darajasi ELISA yordamida baholandi va sitokinlar Vector-Best immunoassaylari yordamida aniqlandi.
Natijalar: Zardobdagi D vitamini darajasi va IL-6 konsentratsiyasi o'rtasida sezilarli teskari korrelyatsiya kuzatildi (r = -0.42, p < 0.05). Og'ir kardit bilan og'rigan bolalarning aksariyati D vitamini yetishmovchiligi va IL-6 va IFN-γ darajasining oshishi bilan og'rigan. Davolashdan so'ng, sitokin darajasi pasaygan, D vitamini holati esa biroz yaxshilangan.Xulosa: D vitamini yetishmovchiligi yallig'lanish faolligini bashorat qiluvchi omil bo'lib xizmat qilishi mumkin va yallig'lanishga qarshi sitokinlarning, ayniqsa IL-6 ning oshishi bilan bog'liq. D vitamini holatini baholash RI bilan og'rigan bolalarda immunitet vositasida faollikni erta aniqlashga yordam beradi va profilaktika va terapevtik strategiyalarni boshqaradi.
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