GEPATIT B BILAN KASALLANGAN AYOLLARDA HOMILADORLIK PAYTIDA ONA VA YANGI TUG'ILGAN CHAQALOQ UCHUN SALBIY OQIBATLARNI KAMAYTIRISH YO'LLARI
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homiladorlik, surunkali gepatit B, perinatal natijalar, immunoprofilaktika##article.abstract##
Surunkali gepatit B (HBV) homiladorlikning salbiy oqibatlari va perinatal patologiyaning asosiy infekcion sabablaridan biri bo'lib qolmoqda. Sitolitik sindrom va jigarning metabolik funktsiyalarining buzilishi bilan kechadigan virusli replikatsiya gestoz, anemiya, platsenta etishmovchiligi, erta tug'ilish va infektsiyani vertikal ravishda yuqtirish xavfining oshishiga olib keladi.Surunkali gepatit B bilan og'rigan homilador ayollarni kompleks davolashni taklif qilish virusli nagruzkani 2,6 martadan ko'proq kamaytirishni (p<0,01), ALT, AST va bilirubinni normallashtirishni va elastografiya (FibroScan CAP) bo'yicha fibroz darajasini pasaytirishni ta'minladi. Akusherlik asoratlari 1,5-2 marta, erta tug'ilish 16,1% dan 8,1% gacha kamaydi (p<0,05). Tadqiqot guruhidagi bemorlarda uchinchi trimestrdagi kardiotokografiya natijalari yurak ritmi variabelligi va akcelerasiyalar tezligining sezilarli darajada oshishi (p<0,01), kechki deselerasiyalarning pasayishi va homila holati indeksining normallashishini ko'rsatdi (FCI = 1,10 ± 0,25). Yangi tug'ilgan chaqaloqlarning tana vazni va yashash xolati yuqoriroq bo'lib, HBV ning vertikal uzatilish chastotasi 5,7% dan 1,2% gacha kamaydi (p<0,05). Gepatit B bilan kasallangan homilador ayollarni kompleks davolash virus faolligini kamaytirishga, jigar faoliyatini barqarorlashtirishga, fetoplasental qon aylanishini yaxshilashga va neonatal HBV infektsiyasini oldini olishga yordam beradi.
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