GENETIK POLIMORFIZM PGR (RS1042838) VA UNING GENITAL PROLAPSNING TURLI KLINIK ShAKLLARI BILAN BOG‘LIQLIGI
##article.subject##:
genital prolaps, progesteron retseptorlari, polimorfizm, gen, PGR (rs1042838), chastota, allel, genotip, tashuvchilar.##article.abstract##
Bemor ayollarda genital prolapsning turli klinik shakllari bilan progesteron retseptor geni PGR (rs1042838) polimorfizmi o‘rtasidagi bog‘liqlik o‘rganildi. Genetik tahlil standart PSR usuli orqali DNK namunalari asosida amalga oshirildi. Kompleks tahlil natijalari PGR (rs1042838) genidagi allel va genotiplar tarqalish xususiyatlarida aniq tendensiyalar mavjudligini ko‘rsatdi. Xususan, genital prolaps bilan kechuvchi chanoq tubi yetishmovchiligi holatlarida salbiy prognostik ahamiyatga ega bo‘lgan allel va genotiplarning tashuvchilarida kasallik rivojlanishi xavfi va uning og‘irlashish ehtimoli statistik jihatdan ishonchli darajada yuqoriligi aniqlandi.
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