YANGI COVID-19 KORONAVIRUS INFEKSIYASIDA ENDOTELIAL DISFUNKTSIYANING AHAMIYATI. (ADABIYOT SHARHI)
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Endotelial disfunktsiya ko'plab kasalliklar va holatlar, jumladan, yangi koronavirus infektsiyasi COVID-19 va post-Covid sindromining faol bosqichida rivojlanishida muhim rol o'ynaydi. Endotelial disfunktsiya bilan bog'liq bo'lgan va mikrosirkulyatsiya tizimining, shu jumladan endotelitning keng miqyosli shikastlanishi bilan tavsiflangan tizimli angiopatiya COVID-19 ga xos bo'lgan ma'lum morfologik ko'rinishlarga ega. SARS-CoV-2 virusi nafas yo'llarining shilliq qavatidagi goblet hujayralariga hujum qiladi. COVID-19 diffuz alveolyar shikastlanish orqali rivojlanadi, bu gialin membrana shakllanishiga va o'pka shishiga olib keladi. Nafas olish yo'llarining bunday shikastlanishi SARS-CoV-2 virusining alveolyar epiteliya hujayralari va endotelial hujayralarga ta'siri, shuningdek immunologik ta'sirlar, jumladan perivaskulyar yallig'lanish tufayli yuzaga keladi. Bu omillarning barchasi birgalikda endotelial-epitelial to'siqning buzilishiga va oqsil ekssudatining alveolyar bo'shliqqa kirib borishiga olib keladi, bakterial va qo'ziqorin florasi uchun fon yaratadi.
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Статья поступила в редакцию 10.05.2024; одобрена после рецензирования 21.06.2024; принята к публикации 29.06.2024.
The article was submitted 10.05.2024; approved after reviewing 21.06.2024; accepted for publication 29.06.2024.
Информация об авторах:
Самибаева Умида Хуршидовна- Ассистент Самаркандский государственный медицинский университет, Самарканд, Узбекистан. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981, +998902705686.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Самибаева У.Х. — идеологическая концепция работы, написание текста; редактирование статьи; сбор и анализ источников литературы, написание текста.
Information about the authors:
Information about the authors:
Samibaeva Umida Khurshidovna - Assistant, Samarkand State Medical University, Samarkand, Uzbekistan. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981, +998902705686.
Sources of funding: The work did not have special funding.
Conflict of interest: The author declares that there are no obvious or potential conflicts of interest related to the publication of this article.
Authors' contributions:
Samibaeva U.Kh. — ideological concept of the work, writing the text; article editing; collection and analysis of literature sources, writing text.
