ОЦЕНКА РОЛИ ПОЛИМОРФНЫХ ГЕНОВ ММП-9 И ТИМП-1 ПРИ МИОКАРДИТЕ, ВЫЗВАННОМ SARS-COV-2
Ключевые слова:
коронавирусная болезнь 2019, вирус тяжелого острого респираторного синдрома, матриксные металлопротеиназ, тканевые ингибитор матриксных металлопротеиназАннотация
Имеющиеся в настоящее время данные свидетельствуют о том, что полиморфизмы генов ММП и ТИМП могут оказывать существенное влияние на степень воспаления и структурные изменения миокарда при вирусных инфекциях, включая COVID-19. Однако результаты исследований остаются противоречивыми из-за различий в исследуемых группах, методологиях и критериях оценки. Кроме того, большинство проведенных исследований были сосредоточены на общих аспектах воспаления при миокардите, а точные механизмы, связанные с генетическими вариантами в генах ММП и ТИМП, изучены недостаточно.
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