CLINICAL FEATURES OF PARKINSON'S DISEASE IN THYROID HOMEOSTASIS DISRUPTION
Keywords:
thyroid homeostasis, neurodegenerative diseases, EMG, MMSE testAbstract
Purpose: to study the influence of thyroid homeostasis disorders on the development of Parkinson's disease and dementia.
Methods: The study employed clinical-neurological methods, laboratory indicators (TSH, TRH, T3, T4), neuroimaging techniques, neurological assessments (the Hoehn and Yahr scale, UPDRS), the MMSE (Mini-Mental State Examination), and methods of multivariate statistical analysis.
Results: The tremor-dominant form of Parkinson's disease is associated with lower levels of TSH (thyroid-stimulating hormone) compared to the akinetic-rigid type. Higher levels of T3 are correlated with less severe manifestations of the disease. The degradation of dopaminergic neurons, along with an imbalance in TRH (thyrotropin-releasing hormone) levels, may contribute to motor dysfunction and tremors in patients with Parkinson's disease. Furthermore, both hypothyroidism and hyperthyroidism are linked to increased oxidative stress, which disrupts the dopamine system and leads to neuronal apoptosis, potentially resulting in dementia.
Conclusion. Thus, in the first control group of patients with Parkinson's disease (PD) and hypothyroidism, compared to the second control group consisting solely of PD patients, there were progressive symptoms such as increased tremor and cognitive dysfunction. These symptoms may be related to the interaction between PD and hypothyroidism. Assessing the dynamics of motor and cognitive impairments at various stages of the disease allows for timely correction of motor disorders in collaboration with endocrinologists and neurologists, as well as stabilization of the disease course. It is recommended that patients with PD be screened for hypothyroidism, and that patients with hypothyroidism be evaluated for PD.
References
Abdullaeva N. N. et al. Pain syndrome in Parkinson's disease // Journal of Neurology and Neurosurgical Research. - 2022. - Vol. 3. - No. 6. (in Uzb).
Artemyev D. V., Age-related aspects of Parkinson's disease. Guide for doctors based on the materials of the II National Congress, M-2011.(in Russ).
Aliev M.A., Mamadaliev A.M., Mamadalieva S.A. Research of essential elements composition in the cerebrospinal fluid in patients with outcomes of traumatic brain injury // International scientific journal, 2015. No. 9. P. (in Uzb).
Aliev M.A., Mamadaliev A.M., Mamadalieva S.A. Research of essential elements composition in the cerebrospinal fluid in patients with outcomes of traumatic brain injury // International scientific journal, 2015. № 9. С. (in Uzb).
Artemyev D. V., Age-related aspects of Parkinson's disease. Guide for doctors based on the materials of the II National Congress, M-2011.(in Russ).
Антонова К.В. Психические расстройства в клинике эндокринных заболеваний. РМЖ. 2006; 26: 1889. (in Russ).
Bridwell R., Willis G., Gottlieb M., et al. Decompensated hypothyroidism: a review for the emergency clinician. Am. J. Emerg. Med. 2021; 39: 207–212.
Boyzhuraev O. N., Toshtemirov Sh. I., Djurabekova A. T. Results of treatment of patients with vascular parkinsonism with the drug mydocalm // Editor-in-chief: Sukiasyan A. A., PhD, Senior Lecturer, 2015. P. 184. (in Uzb).
Burieva D. M., Khakimova S. Z., Djurabekova A. T. Comparative study of the function of maintaining vertical posture in healthy individuals and patients with parkinsonism // Innovative science, 2015. No. 6-2. (in Uzb).
Van Boxtel M., Menheere P., Bekers O., et al. Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology. 2004; 29 (7): 891–898.
Eshimova Sh.K., Khakimova S.Z., Dzhurabekova A.T. Evaluation of the effectiveness of antitremor drugs in patients with essential tremor // Innovative Science, 2016. No. 1-3 (13). (in Uzb).
Grachev I.S., Fedorova N.V. Drug-induced dyskinesias in Parkinson's disease: classification, impact on quality of life and approaches to treatment. Guide for physicians based on the materials of the 1st National Congress, M-2018.-P. 88-9188.(in Russ).
Kopishinskaya S.V., Gustov A.V., Makushina E.V. et al. Premotor Parkinson's disease. Journal "Remedium", 04.2016. 93. (in Russ).
Levin O.S., Fedorova N.V., Shtok V.N. Differential diagnostics of parkinsonism // Journal of neurology and psychiatry -2019. - No. 3. - P. 54-60.(in Russ).
Khakimova S.Z., Djurabekova A.T. Cognitive impairment in Parkinson's disease // Vestnik Vrachey, 2015. P. 49. (in Uzb).
Alimjanovich , R. Z., Maxammatkulovich , R. N., & Khikmatovich , K. K. (2022). Age Features of the Prevalence of Prostate Cancer in Uzbekistan. Central Asian Journal of Medical and Natural Science, 3(5), 154-157. Retrieved from
Rizaev Jasur , Rakhimov Nodir , Kodyrov Khamidullo , Shakhanova Shakhnoza . Study of prostate cancer death by regions of the republic of Uzbekistan.Journal of Biomedicine and Practice. 2022, vol . 7, issue 5, pp.202-210
Shavkatovna S. S., Makhammatkulovich R. N., Ugli M. S. T. ASPECTS OF SARCOPENIA SYNDROME IN ONCOLOGICAL PRACTICE: DIAGNOSIS AND TREATMENT //The American Journal of Medical Sciences and Pharmaceutical Research. – 2024. – Т. 6. – №. 02. – С. 16-25
Storch A, Trenkwalder C, Oehlwein C. High-dose treatment with pergolide in Parkinson‘s disease patients with motor fluctuations and dyskinesias. Parkinsonism Relat Disord 2015;11:393–398.
Taylor KS, Cook JA, Counsell CE. Heterogeneity in male to female risk for Parkinson‘s disease. J Neurol Neurosurg Psychiatry. 2017;78:905–6.
Thuy C. Vu1, John G. Nutt. Progression of motor and nonmotor features of Parkinson's disease and their response to treatment - 2016; 2016 The Authors. British Journal of Clinical Pharmacology Volume 74, Issue 2, pages 267–283, August 2015.
