THE SIGNIFICANCE OF SOME MICROELEMENTS AND VITAMIN D IN CHANGES IN THE MINERAL COMPOSITION OF BONE TISSUE OF EXPERIMENTAL ANIMALS IN THE POST-PRODUCTION PERIOD
Keywords:
osteoporosis, reproductive period, post-reproductive period, vitamin D, calcium, magnesiumAbstract
Osteoporosis is a systemic metabolic disease of the skeleton, and is considered a severe pathology of the musculoskeletal system, mainly in the elderly, accompanied by a gradual decrease in mineral density and a sharp violation of the microarchitectonics of bone tissue. As a result of such changes in the bone tissue, osteoporotic fractures of various localization occur even with minimal trauma. Given the direct dependence of bone mineral density on the amount of vitamin D, calcium and magnesium in the blood serum, we studied the amount of vitamin D and these trace elements in the blood plasma of rabbits of the reproductive and post-reproductive period.The results of our studies have shown that the amount of vitamin D, calcium and magnesium in the blood plasma of rabbits of the post-reproductive period is sharply reduced compared to rabbits of the reproductive period. These data indicate a violation of the synthesis of vitamin D, absorption and absorption of calcium and magnesium, which is one of the reasons for the development of senile osteoporosis in rabbits of the post-reproductive period. Violation of the metabolism of substances such as vitamin D, calcium and magnesium in animals in the post-reproductive period is associated with age-related changes in the wall of the organs of the digestive canal at this age.
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Холхужаев Фаррух Икромович - PhD, ассистент кафедры травматологии и ортопедии Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: farrux.xolxujayev@mail.ru https://orcid.org/0009-0007-0823-5110
Маюсупова Бивифотима Мухаматсобирзода – студент лечебний факультет 5- курса, СамГМУ. Е-mail: fmayusupova@gmail.com https://orcid.org/0009-0000-7307-6274
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Холхужаев Ф.И. — идеологическая концепция работы, написание текста; редактирование статьи;
Маюсупова Б.М—написание текста.
Information about the authors:
Kholkhujaev I Farrukh - Ph.D. assistant at the Department of Traumatology and Orthopedics, Samarkand State Medical University, Samarkand, Uzbekistan. Е-mail: farrux.xolxujayev@mail.ru
Mayusupova M Bivifotima — student 5th year, Samarkand State Medical University, Samarkand, Uzbekistan. Е-mail: fmayusupova@gmail.com https://orcid.org/0009-0000-7307-6274
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Kholkhujaev F.I. — ideological concept of the work, writing the text; editing the article;
Mayusupova B.M —writing the text.
