A MODERN PERSPECTIVE ON LOCAL TREATMENT OF RECURRENT APHTHOUS STOMATITIS
Keywords:
: recurrent aphthous stomatitis, local treatment, phage therapy, bacteriophage, epithelialisationAbstract
Recurrent aphthous stomatitis (RAS) remains a significant problem in dentistry due to its high prevalence and considerable impact on patients’ quality of life. The aim of this study was to evaluate the clinical efficacy of topical phage therapy in RAS. Materials and methods. The study included 23 patients with a moderate form of the disease, divided into the main group (treated with bacteriophage) and the comparison group (standard therapy). The dynamics of pain, epithelialisation time, and recurrence rate were assessed. Results. Patients in the main group demonstrated earlier pain reduction (on days 2–3), faster epithelialisation (4.1 ± 0.6 days vs. 6.3 ± 0.8 days in the comparison group, p<0.05), and a lower recurrence rate during 6 months of follow-up (25% vs. 58.3%). Conclusions. The obtained results confirm the high clinical efficacy of bacteriophage and its potential as a promising topical therapeutic approach in RAS management.
References
Abed J., et al. Phage therapy in inflammatory disorders. World J Gastroenterol. 2017;23(34):6530–6541.
Albanidou-Farmaki E., et al. Psychosocial stress as a trigger of recurrent aphthous stomatitis. Oral Dis. 2008;14:247–252.
Altenburg A., et al. The treatment of recurrent aphthous stomatitis. Dtsch Arztebl Int. 2014;111(40):665–673.
Chiang C.P., et al. Recurrent aphthous stomatitis – etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formos Med Assoc. 2019;118(9):1279–1289.
Kamilov Kh.Sh., Shukurova G.S. Index of severity in chronic recurrent aphthous stomatitis. Stomatology. 2013;4:45–48. (in Russ)
Natah S.S., et al. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Surg. 2004;33:221–234.
Preeti L., Magesh K.T., Rajkumar K., Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252–256.
Scully C., Porter S. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med. 2008; 37 (5):283–293.
Sun A., et al. Genetics and recurrent aphthous stomatitis: a review. J Oral Pathol Med. 2015;44 (7):475–482.
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Jasim, S. A., Gupta, J., Uthirapathy, S., R., R., Kazmi, S. W., & Rizaev, J. A. (2025). A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1–17.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
