THE ROLE AND CHARACTERISTICS OF DOPAMINE IN THE RETINAL LAYER OF THE EYE IN PATIENTS WITH PARKINSON'S DISEASE
Keywords:
Parkinson's disease, neurodegenerative diseas, retinal layer, dopamine.Abstract
Purpose: A decrease in dopamine in the retina occurs before the symptoms of Parkinson's disease appear. This condition may be a precursor to the disease, and the study of its characteristics is currently underway.
Methods: To study the role and properties of dopamine in the retinal layer of the eye in patients with Parkinson's disease, optical coherence tomography (OCT) was used to assess the thickness of the retinal nerve fiber layer and the nerve fiber layer in patients.
Results: Pupilometric studies can help identify subclinical stages of Parkinson's disease and assist in evaluating the effectiveness of therapy for this condition.
Conclusion. It has been established that dopamine is a neurotransmitter not only in the brain but also in the retina. Dopamine-producing cells and dopamine receptors are involved in all structural formations of the eye. In Parkinson's disease, changes in visual function occur not only in the retina but also in the entire visual apparatus. This is associated with peripheral manifestations of the disease and may precede the onset of known motor disorders.
References
Boyzhuraev O. N., Toshtemirov Sh. I., Djurabekova A. T. Results of treatment of patients with vascular parkinsonism with the drug mydocalm // Editor-in-chief: Sukiasyan A. A., PhD, Senior Lecturer, 2015. P. 184. (in Uzb).
Burieva D. M., Khakimova S. Z., Djurabekova A. T. Comparative study of the function of maintaining vertical posture in healthy individuals and patients with parkinsonism // Innovative science, 2015. No. 6-2. (in Uzb).
Grachev I.S., Fedorova N.V. Drug-induced dyskinesias in Parkinson's disease: classification, impact on quality of life and approaches to treatment. Guide for physicians based on the materials of the 1st National Congress, M-2018.-P. 88-9188.(in Russ).
Kopishinskaya S.V., Gustov A.V., Makushina E.V. et al. Premotor Parkinson's disease. Journal "Remedium", 04.2016. 93. (in Russ).
Meuer SM, Myers CE, Klein BE, et al. The epidemiology of vitreo-retinal interface abnormalities as detected by sd-oct: the beaver dam eye study. Ophthalmology. 2015;122(4):787-795. https://doi. org/10.1016/j.ophtha.2014.10.014.
Куликов А.Н. Морфофункциональное состояние эндотелия "свежих" и консервированных по В.П. Филатову роговиц /А.Н. Куликов, Г.А. Софронов, Э.В. Бойко //Вестник Российской военно-медицинской академии. - 2006. - с. 44-47. (in Russ).
Щуко А.Г. Оптическая когерентная томография в диагностике глазных болезней / Под ред. проф. А.Г. Щуко, проф. В.В. Малышева. - М.: ГЭОТАР-Медиа, 2010. - 128 с. Shchuko AG. Opticheskaya kogerentnaya tomografiya v diagnostike glaznykh boleznei. Ed. by A.G. Shchuko, V.V. Malyshev. Moscow: GEOTAR-Media; 2010. 128 р. (In Russ.)
Sonmez K, Capone A, Trese MT, et al. Vitreomacular traction syndrome: impact of anatomical configuration on anatomical and visual outcomes. Retina. 2008;28(9):1207-1214. https://doi. org/10.1097/IAE.0b013e31817b6b0f.
Duker JS, Kaiser PK, Binder S, et al. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013;120(12): 2611-2619. https://doi.org/10.1016/j.ophtha.2013.07.042.
