CLINICAL ANALYSIS OF POSTCHOLECYSTECTOMY SYNDROME
Keywords:
postcholecystectomy syndrome, cholecystokinin, cholecystectomy.Abstract
The study was conducted on the basis of data obtained from a survey of 464 patients who underwent surgery to remove the gallbladder due to cholelithiasis. To develop a clinical classification of PCES and create an algorithm for examining these patients, the results of clinical, laboratory and instrumental studies of 388 patients who underwent inpatient treatment at the multidisciplinary clinic of Samarkand State Medical University in the period from 2018 to 2023, who were diagnosed with “Postcholecystectomy syndrome”, were analyzed. , selected by random sampling.
This work is a comprehensive study of postcholecystectomy syndrome (PCES) associated with postoperative consequences of laparoscopic cholecystectomy. The work analyzes clinical variants of PCES, including dyspeptic, pain, icteric, asymptomatic and Charcot variant. Particular attention is paid to the differential diagnosis between functional and structural disorders of the biliary tract using the concentration of cholecystokinin in blood serum. The study also discusses the significance of the lithogenic properties of bile, changes in humoral regulation and exocrine liver disorders in the formation of PCES. The work emphasizes the need for clinical monitoring and correction of biliary insufficiency in patients after cholecystectomy.
References
Abdurakhmanov D. Sh., Kurbaniyazov Z. B., Mardonov B. A., Sayinaev F. K. RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH ABDOMINAL HERNIA AND COMBINED ABDOMINAL PATHOLOGY. 2022, VOLUME-1, 18. (in Russ).
Abdurakhmanov D. Sh., Mardonov B. A., Rakhmanov K. E., Davlatov S. S. Clinical evaluation of gernio and abdominoplasty in patients with ventral hernia and morbid obesity. Journal of Biomedicine and Practice, 2021. 211-221.
Belyaev K.K., Fedorov A.I. Endoscopic papillosphincterotomy in the treatment of choledocholithiasis. Surgical practice, 2016.-№8. 23-30. (in Russ).
Galperin E.I. etc. Scar structures of the bile ducts. М. 1982. 219-233 (in Russ).
Kurbaniyazov Z.B., Mardanov B.A., Rakhmanov K.E. "Forecasting the results of simultaneous operations on the abdominal organs and abdominal wall in patients with ventral hernia." Problems of biology and medicine 1 (2020): 58-61. (in Russ).
Shalimov A.A., Shalimov S.A., Nichitailo M.E., Domansky B.V. Surgery of the liver and bile ducts. - Kyiv: "Healthy". 1993. 473-475. (in Russ).
Anderson K.J., Lee S.H. Endoscopic papillotomy in the treatment of choledocholithiasis: a review // International Surgery Journal. 2016. No8. 23-30.
Kurbaniyazov Z.B., Mardanov B.A. Surgery of iatrogenic injuries of the trunk GI tract: clinic, diagnosis and surgical treatment (literature review)//Journal of Biomedicine and Practice. – 2023. – Т. 8. – №. 1.
Brown A.B., Davis L.M. Modern techniques in the diagnosis and treatment of reflux gastritis // Clinical Gastroenterology. 2018. No. 3. P. 12-20.
Mardonov B., Kurbaniyazov Z., Davlatov S., Rakhmanov K. Rationale for simultaneous operations on the abdominal organs and the abdominal wall in patients with a ventral hernia. International Journal of Pharmaceutical Research, 2020, 12, 1922–1930.
