THE EFFECT OF GASTROINTESTINAL TRACT DYSFUNCTION ON MORTALITY IN PATIENTS WITH SEVERE BURNS
Keywords:
Burns, burn shock, severity of burns, gastrointestinal dysfunction, death from burns.Abstract
This retrospective analysis showed that patients with severe burn injuries with a total burn area (TOA) of 20% > 50%, of which the area of deep burns (ADB) > 25%, were hospitalized in the period from January 2015 to December 2024, with a demographic indicator ranging from 7 to 75 days or a fatal outcome, beyond which burning factors, burning depth, attention is paid to the scale that determines the severity of burns (Frank index), which assesses the condition of organs and systems, the scale assessment (SOFA), as well as the set of symptoms that determine the severity of burn shock and the degree of penetrating respiratory damage. This also includes monitoring gastrointestinal dysfunction, nausea, vomiting, diarrhea or constipation, bleeding from gastrointestinal ulcers, paralytic intestinal obstruction, enzymatic disorders, and the patient's length of stay in the hospital and intensive care units.
References
Brusselaers N., Monstrey S., Vogelaers D., Hoste E., Blot S. – Severe Burn Injury in Europe: A Systematic Review of Incidence, Etiology, and Mortality. Crit Care. 2010;14(5): R188.
Smolle S., Cambiaso-Daniel J., Forbes A.A., Wurzer P., Hundeshagen G., Branski L.A., et al. – Recent Trends in Worldwide Burn Epidemiology: A Systematic Review. Burns. 2017;43(2):249–57.
Nilsson K.B., Duethman N.K., Howard J.M., Moncur M., Wood J.G. – Burns: Pathophysiology of Systemic Complications and Current Treatment. J Burn Care Res. 2017;38(1):e469–81.
Porter S., Herndon D.N., Sidossis L.S., Børsheim E. – Impact of Severe Burns on Skeletal Muscle Mitochondrial Function. Burns. 2013;39(6):1039–47.
Gacouin A., Camus C., Gros A., Isslame S., Marqué S., Lavoué S., et al. – Constipation in Long-Term Mechanically Ventilated Patients: Associated Factors and Impact on Intensive Care Unit Outcomes. Crit Care Med. 2010;38(10).
Trexler S.T., Landy J.B., Chang K.K., Nitzschke S.L., Burns S.J., Shields B.A., et al. – Prevalence and Consequences of Delayed Defecation in Critically Ill Adult Patients with Thermal Injuries. J Burn Care Res. 2014;35(4):224–9.
Kong E.L., Burns B. – Narcotic Bowel Syndrome [Updated May 4, 2022]. In: StatPearls. Treasure Island (FL); 2022.
Ng J.W.G., Cairns S.C., O’Boyle C.A. – Management of the Lower Gastrointestinal Tract in Burns: A Comprehensive Review. Burns. 2016; 42(4):728-37.
Kadesky K., Purdue G.F., Hunt J.L. – Acute Pseudo-obstruction in Critically Ill Burn Patients. J Burn Care Rehabil. 1995;16(2 Pt 1):132-5.
Ivey M.E., Possenti P.P., Kepros J., Atwe N.A., D’Auto M., Palmer J., et al. – Abdominal Compartment Syndrome in Burn Patients. J Burn Care Rehabil. 1999; 20(5):351-3.
Strang S.G., van Lieshout E.M., Breederveld R.S., van Waes O.F. – Systematic Review of Intra-abdominal Pressure in Severe Burn Patients. Burns. 2014;40(1):9-16.
Souci S., Tacchory M., De Timovsky S., Deprez F., Chossard M., Frattani A., et al. – Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burn Patients – A Case-Control Study. Shock. 2019;51(2):153-60.
Wang Z.T., Yao Y.M., Xiao G.H., Sheng C.Z. – Risk Factors for the Development of Gut-derived Bacterial Translocation in Rats with Thermal Injuries. World J Gastroenterol. 2004;10(11):1619-24.
Xiao S.K., Zhu S., Xia C.F., Lu W., Wang G.K., Ben D.F., et al. – Prevention and Treatment of Gastrointestinal Dysfunction After Severe Burns: A Brief Review of 30 Years of Clinical Experience. World J Gastroenterol. 2008;14(20):3231–5.
Cancio L.C., Kramer G.C., Hoskins S.L. – Gastrointestinal Fluid Resuscitation in Burn Patients. J Burn Care Res. 2006;27(5):561-9.
Graves T.A., Chioffi V.G., Vaughn G.M., Pratt L., Ironim J.D., McManus V.F., et al. – Effects of Low-dose Dopamine on Renal Function in Burn Patients. J Trauma. 1993;35(1):97-102 (discussion
S.E. Mamarajabov , Zh.A. Rizaev , S.R. Baimakov // Current aspects of medical activity: collection of articles of the I International Scientific- practical conference, Kirov - Samarkand, June 21, 2021. – Kirov: Federal State Budgetary Educational Institution of Higher Education “Kirov State Medical University” of the Ministry of Health of the Russian Federation, 2021. – P. 209-212. – EDN DOETDC.
