VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER
Keywords:
острая ревматическая лихорадка, дефицит витамина D, ИЛ-6, цитокины, дети, воспаление, иммунный ответAbstract
Background: Acute rheumatic fever (ARF) remains a significant pediatric health concern in developing countries. Recent studies suggest that vitamin D plays an important immunomodulatory role in inflammatory diseases.
Objective: To investigate the relationship between vitamin D deficiency and inflammatory cytokines (IL-1β, IL-6, IL-8, IFN-γ) in children with acute rheumatic fever.
Methods: The study included 60 children aged 5–15 years diagnosed with ARF. As part of this study, the concentration of 25(OH)D in children with acute rheumatic fever (ARF) was evaluated and compared with data from healthy children of the same age group. Serum levels of 25(OH)D and proinflammatory cytokines were measured before and after treatment. Vitamin D levels were assessed by ELISA, and cytokines were determined using Vector-Best immunoassays.
Results: A significant inverse correlation was observed between serum vitamin D levels and IL-6 concentrations (r = -0.42, p < 0.05). The majority of children with severe carditis presented with pronounced vitamin D deficiency and elevated IL-6 and IFN-γ levels. After treatment, cytokine levels decreased while vitamin D status modestly improved.
Conclusion: Vitamin D deficiency may serve as a predictor of inflammatory activity in ARF and correlates with elevated proinflammatory cytokines, particularly IL-6. Assessing vitamin D status may help in the early detection of immune-mediated activity in children with ARF and guide preventive and therapeutic strategies.
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