EFFECT OF CHRONIC STRESS ON GENERATIONAL HYPOCAMP MORPHOLOGY
Keywords:
stress, hippocampus, neurocytes, morphology, neurogenesis, pathological changes, laboratory rats.Abstract
This article examines the impact of chronic stress on the morphology of the hippocampus. The study compares the hippocampal structure and developmental dynamics of laboratory rat offspring born to stressed mothers with those in a control group. The results indicate that offspring exposed to stress exhibit a reduction in hippocampal neurocytes, vacuolization of the cytoplasm, changes in nuclear and cytoplasmic size, as well as neurocyte lysis. Additionally, the body weight of stressed rat offspring was found to be lower than that of the control group. The obtained data suggest that stress may have a negative impact on hippocampal structure.
References
Behavioral deficits induced by third-trimester equivalent alcohol exposure in male C57BL/6J mice are not associated with reduced adult hippocampal neurogenesis but are still rescued with voluntary exercise / G. F. Hamilton [et al.] // Behavioural Brain Research. – 2016. – Vol. 314. – P. 96-105. – doi: 10.1016/j.bbr.2016.07.052.
Hippocampal abnormalities in youth with alcoholrelated neurodevelopmental disorder [Electronic
resource] / J. Dubek [et al.] // Journal of the International Neuropsychological Society. – 2014. – Vol. 20, iss.– P. 181-191.
Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503–511. doi: 10.1038/35000501
Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747–752. doi: 10.1038/35021093.
Haibe-Kains B, Culhane A, Desmedt C, Bontempi G, Quackenbush J, Sotiriou C. Robustness of breast cancer molecular subtypes identification. Ann Oncol. 2010;21(suppl 4):iv49–iv59.
Liedtke C, Hatzis C, Symmans WF, et al. Genomic grade index is associated with response to chemotherapy in patients with breast cancer. J Clin Oncol. 2009;27(19):3185–3191. doi: 10.1200/JCO.2008.18.5934.
Teschendorff AE, Caldas C. The breast cancer somatic ʻmuta-omeʻ: tackling the complexity. Breast Cancer Res. 2009;11(2):301. doi: 10.1186/bcr2236.
Раза, М., Ризаев, Ж., & Джурабекова, А. (2025). Организационно-адаптационные стратегии улучшения социально-психологической интеграции зарубежных учащихся медицинских вузов. Наука и инновация, 3(15), 37–39.
Irgashev, K. N., & Rizaev, J. A. (2025). Optimization of clinical outcomes in the rehabilitation of patients with non-caries dental lesions manifesting as pathological abrasion. Medical Research Journal, 1(1), 146–151.
Rizaev JA, Khazratov AI, Iordanishvili AK Morphofunctional characteristics of the mucous membrane of the masticatory apparatus in experimental carcinogenesis //Russian Journal of Dentistry. – 2021. – T. 25. – No. 3. – pp. 225-231.
