DISTAND RESULTS OF PATIENTS WITH BREAST CANCER ACCORDING TO STAGE OF DISEASE
Keywords:
mammary cancer, diagnostics, treatment, population survival.Abstract
Introduction: Efficiency of the control of a mammary cancer (МC) is expressed by level of the early diagnostics and the probability of survival of patients on population level.
Aim: The efficiency estimation of five-year survival on population level of women with different stages of mammary cancer (MC) in Тashkent city during 2017-2022 yy.
Material and methods: Data of the conditional Cancer-register (CCR) of TCB of RSSPMCO&R for period 01.07.2017-31.03.2023 yy were used. The five year survival of Tashkent women with the first registered diagnosis MC for this period was estimated. The control date (СD) - 01.04.2023 After all specifications the general number of patients with first registered MC has constituted 3942.
Results: The fraction of the women with MC of 2nd stage constituted 44,9% (CI95%=43,4÷46,5), that was statistically above than at one other stages (p<0,05). The fractions of women with MC of III, IV and without specified stages were significantly more than those in a stages 0-I (p <0,05). The five year survival of patients with MC at population level constituted 79,4 % (CI95 % = 77,9÷81,0) that much more low than in the developed countries of the world. At women with 0-I, II, III, IV stages of MC it has accordingly constituted 93,9% (CI95% = 91,1÷96,6), 88,4% (CI95%=86,6÷90,1), 72,4% (CI95%=68,4÷76,2) and 53,7% (CI95%=46,7÷60,7), at an uncertain stage - 74,6% (CI95%=69,6÷79,7).
Conclusion: The five year survival of the women in conditions of Tashkent city is limited by large prevalence of cases with III and IV and of undetectable stages of MC (45,7%). It means the presence of serious reserves of control of MC which can be revealed by development of practice of MC screening in the conditions of a city.
References
Ahmad A. Breast cancer statistics: Recent trends. //Adv Exp Med Biol. 2019;1 (152):1-7.
Balasubramanian R., Rolph R., Morgan C., Hamed H. (2019). Genetics of breast cancer: management strategies and risk-reducing surgery. // Br.J.Hosp. Med. (Lond). 80 (12): 720-725.
Bray F., Ferlay J., Soerjomataram I. e.a. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries //CA: A Cancer Journal for Clinicians. 68 (6): 394- 424.
Breast cancer: prevention and control // WHO. (https://web.archive.Org/web/20150906121739/http://www.who.-int/cancer/detection/breastcancer/en/indexl .html).
Cancer Survival in England: Patients Diagnosed 2007-2011 and Followed up to 2012 (http://www.ons. gov.uk/ons/dcpl 71778_333318.pdf) (PDF). Office for National Statistics. 29 October 2013.
Kirkwood В.R., Sterne J.A.S. Essential medical statistics / 2nd edition, Oxford. - 2003. – 512p.
McGuire A., Brown J.A., Malone C. e.a. 2015. Effects of age on the detection and management of breast cancer. // Cancers. 7 (2): 908-29;
Olopade O.L, Falkson C.I. (2010). Breast Cancer in Women of African Descent. Springer Science & Business Media, p.5.
SEER Stat Fact Sheets: Breast Cancer. // NCI. - Archived (https://web.archive.Org/web/20140703030149/http://seer.cancer.gov/statfacts/html/breast.html) from the original on 3 July 2014. Retrieved 18 June 2014. (http://seer.cancer.gov/statfacts/html/breast.html)
World Cancer Report. (2008). IARC. Archived from the original (http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/wcr_2008.pdf).
World Cancer Report. (2014). WHO. 2014. pp. Chapter 1.1. ISBN 978-92-832-0429-9.
Кутлумуратов А.Б., Поляков К.И, Вайсбейн И.З, Попов М.С. (2013) О новых тенденциях трехлетней выживаемости онкологических больных на популяционной уровне в Калининградской области// Российский онкологический журнал. – 2013., т.18, №5. – C.42-47. https://rjonco.com/1028-9984/article/view/40038; DOI: https://doi.org/10.17816/onco40038.
Лакин Г.Ф. Биометрия: Учеб. пособие для биол. спец. Вузов — 4-е изд., перераб. и доп. — М.: Высш. шк., 1990. — 352 с.
Мерабишвили В.М. Онкологическая статистика (традиционные методы, новые информационные технологии): Руководство для врачей. Изд-е 2-е, доп-е. Ч I., 2015.- 223с.
Поляков К.И., Кутлумуратов А.Б., Вайсбейн И.З., Попов М.С. Об изменении выживаемости больных со злокачественными новообразованиями молочной железы в Калининградской области.// Здравоохранение Российской Федерации. – 2014, №3. - С.28-34.
Сборник стандартов и клинических протоколов диагностики и лечения злокачественных новообразований / Коллектив составителей, под ред. проф., д.м.н. М.Н. Тилляшайхова. – Ташкент. - 2017. – 254с.
Стрелков Р.Б. Статистические таблицы для экспресс-расчётов стандартной ошибки и доверительных границ при нулевом и стопроцентном значении показателей экспериментальных и клинических данных. – Обнинск, 1982.
Rizaev , J. A. , and A. I. Khazratov . " Cytostructural changes in the oral mucosa in colon cancer." Journal of Biomedicine and Practice 6.5 (2020).
Alshahrani, M. Y., Oghenemaro, E. F., Rizaev, J., Kyada, A., Roopashree, R., Kumar, S., ... & Abosaoda, M. K. (2025). Exploring the modulation of TLR4 and its associated ncRNAs in cancer immunopathogenesis, with an emphasis on the therapeutic implications and mechanisms underlying drug resistance. Human Immunology, 86(1), 111188.
Rizaev JA, Maeda H., Khramova NV Plastic surgery for the defects in the maxillofacial region after surgical resection of benign tumors //Annals of Cancer Research and Therapy. – 2019. – T. 27. – no. 1. – S. 22-23.
