GENETIC POLYMORPHISM OF PGR (RS1042838) AND ITS ASSOCIATION WITH VARIOUS CLINICAL FORMS OF GENITAL PROLAPSE
Keywords:
genital prolapse, progesterone receptors, polymorphism, gene, PGR (rs1042838), frequency, allele, genotype, carriers.Abstract
The relationship between various clinical forms of genital prolapse and the progesterone receptor gene PGR (rs1042838) polymorphism was studied in sick women. Genetic analysis was performed on DNA samples using the standard PCR method. The results of the complex analysis showed clear trends in the distribution of alleles and genotypes in the PGR (rs1042838) gene. In particular, it was found that carriers of alleles and genotypes that have a negative prognostic significance in cases of pelvic floor insufficiency with genital prolapse have a statistically significant higher risk of developing the disease and the likelihood of its worsening.
References
Nasimova N. R. Diagnostika, lechenie, reabilitatsiya i xirurgicheskaya korreksiya genitalnogo prolapsa i seksualnoy disfunksii u jenщin // Tibbiyotda yangi kun. – 2023;8(58), 64–68.(in Uzb)
Nasimova N. R. Dobrovolnaya xirurgicheskaya kontrasepsiya jenщin reproduktivnogo vozrasta, stradayuщix prolapsom tazovыx organov // Nauka i Mir. – 2015; 2. (1) 95–97. (in Russ)
Nasimova N. R. Rezultatы lecheniya i reabilitatsii jenщin s prolapsom genitaliy // Vestnik Tashkentskoy meditsinskoy akademii. – 2024;(1): 143–145. (in Russ)
Negmadjanov B. B., Nasimova N. R., Ganiev F. I. Xirurgicheskoe lechenie prolapsa genitaliy jenщin reproduktivnogo vozrasta // Dostijeniya nauki i obrazovaniya. – 2019;10(51).31–36. (in Russ)
Negmadjanov B. B., Nasimova N. R., Jalolova I. A. Rol estrogennogo defitsita v razvitii i progressirovanii prolapsa genitaliy // Jurnal reproduktivnogo zdorovya i uronefrologicheskix issledovaniy. – 2023; 4. 12–16. (in Russ).
Abulaizi A. et al. Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women //International Urogynecology Journal. – 2020. – Т. 31. – С. 123-130.].
Akın Y, Young M, Elmussareh M, Charalampogiannis N, Gözen AS. The novel and minimally invasive treatment modalities for female pelvic floor muscle dysfunction; beyond the traditional. Balkan Med J. 2018;35:358–66.
Allen-Brady K, Chua JWF, Cuffolo R, Koch M, Sorrentino F, Cartwright R. Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse. Int Urogynecol J. 2022;33:67–82.
Cartwright R. et al. Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women //American journal of obstetrics and gynecology. – 2015. – Т. 212. – №. 2. – С. 199. e1-199. e24.
Deng Z-M, Dai F-F, Yuan M-Q, Yang D-Y, Zheng Y-J, Cheng Y-X. Advances in molecular mechanisms of pelvic organ prolapse (Review). Exp Ther Med. 2021;22:1009.
Shakhanova S. et al. MELANOMA OF THE SKIN AND PREGNANCY //Eurasian Journal of Academic Research. – 2023. – T. 3. – No. 3. – pp. 120-128.
Abdurakhmonov Jurabek , Rahimov Nodir , Shakhanova Shakhnoza . Modern view on ascite in ovarian cancer. Journal of Biomedicine and Practice . 2022, vol . 7, issue 4, pp . 130-139
Jasur Rizayev Alimjanovich , Larisa Rubenovna Agababyan , Anvar Ibragimovich Kamalov AYOLLARDA TUG'RUQDAN KEYINGI QON KETISHLARNI OLDINI OLISH VA ULARGA QARSHI KURASHISH BO'YICHA KO'RSATILAYOTGAN XIZMATLAR SIFATINING MONITORINGINI TASHKIL ETISH // Oriental Renaissance: Innovative, educational, natural and social sciences Volume 1_ ISSUE 10 202 1 p.m. 166-169
Alimjanovich JR, Agababyan LR, Kamalov AI Prevention and Treatment of Postpartum Hemorrhage //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – T. 2. – No. 4. – S. 204-209.
Rizaev Jasur Alimjanovich , Agababyan Larisa Rubenovna , Davlatova Aziza, Ahmedova Aziza Tayirovna , Rasulova Feruza Golibovna , The state of the oral cavity in pre-pregnant women, Journal of reproductive health and uronephrology research 2023, vol. 4, issue 4, pp7-11
