ENHANCING INTENSIVE CARE FOR PATIENTS FOLLOWING CORONARY ARTERY BYPASS GRAFTING (LITERATURE REVIEW)
Keywords:
coronary heart disease, coronary artery bypass grafting, artificial blood circulation, cytokines, ulinastatin, systemic inflammatory reaction syndromeAbstract
Among the leading causes of death in the adult population, coronary heart disease (CHD) is one of the foremost. Both international and Russian guidelines for the treatment of CHD recommend a collaborative approach when selecting surgical revascularization, particularly coronary artery bypass grafting (CABG). Generally, CABG can be performed using two types of surgical interventions: one with cardiopulmonary bypass (CPB) and cardiac arrest, and another on a beating heart without CPB. The key difference between these approaches lies in the use of CPB and the stoppage of the heart during surgery in the first method, while the second involves surgery on a functioning heart. Both surgical interventions and the use of CPB activate the complement system and trigger the release of cytokines, leading to a systemic inflammatory response. IL-6, IL-1b, and tumor necrosis factor alpha (TNF-a) are the primary mediators of the acute phase of the inflammatory response. Analysis indicates that the early postoperative administration of ulinastatin inhibits the sequestration and activation of neutrophils, reduces the typical postoperative rise in cytokine levels, and alleviates systemic inflammatory response syndrome, pulmonary microvessel permeability, and postoperative pulmonary edema.
References
Abdurakhmanov, A.A. Coronary artery bypass surgery: the current state of the problem / A. A. Abdurakhmanov // Bulletin of Emergency Medicine. – 2019. Vol. 12, No. 4. – pp. 85-90. (in Russ)
Abramovich, S.G. Monitoring the effectiveness of therapeutic physical factors: diagnostic technologies. Part II: studies. manual / S.G. Abramovich – Irkutsk: RIO IGMAPO, 2019. – 56c. (in Russ)
Akchurin, R.S. Modern trends in coronary surgery, R.S. Akchurin, A.A. Shiryaev, V.P. Vasiliev and others // Pathology of blood circulation and cardiac surgery. – 2017. – Vol.21, No. 3S. – pp.34-44.(in Russ)
Mallaev, C., Matlubov, M., & Yusupov, J. (2020). Nutritional support for patients with covid-19 in the intensive care unit. Journal of Cardiorespiratory Research, 1(SI-1), 63-64 (in Russ).
Matlubov, M. M., Khamdamova, E. G., & Yusupov, J. T. (2022). The choice of the method of anesthesia in women with concomitant hypertension during hysterectomies. Journal of Integrated Education and Research, 1(5), 49-54. (in Russ).
Matlubov, M. M., Yusupov, J. T., & Mukhamedieva, N. U. (2020). Preoperative Preparation Of Elderly Patients With Concomitant Hypertension In The Practice Of Ophthalmic Surgery. The American Journal of Medical Sciences and Pharmaceutical Research, 2(11), 8-15.
Matlubov, M. M., Yusupov, J. T., & Sharipov, I. L. (2022). Improving the methods of anesthetic treatment in women with concomitant cardiovascular pathology during uterine removal operations. Journal of Integrated Education and Research, 1(5), 41-48. (in Russ)
Matlubov, M. M., Yusupov, J. T., Mallayev, S. S., & Khamrayev, K. H. (2020). Optimization of anesthesiological assistance in women with arterial hypertension in hysterectomy. Достижения науки и образования, (5), 82-86.
Matlubov, M. M., Yusupov, J. T., Mallayev, S. S., & Khamrayev, K. H. (2020). Optimization of anesthesiological assistance in women with arterial hypertension in hysterectomy. Достижения науки и образования, (5), 82-86.
Matlubov, M. M., Yusupov, J. T., Saidov, M. A., Zhoniev, S. S., & Mollaev, I. U. (2022). The role of artificial blood circulation in the development of postoperative cognitive dysfunction. Journal of Cardiorespiratory Research, 1(4), 15-20. (in Russ).
Matlubov, M., Khamdamova, E., & Yusupov, J. (2020). Tactics of intensive therapy and anesthesia in pregnant women and women in labor infected and sick with covid-19. Journal of Cardiorespiratory Research, 1(SI-1), 66-67. (in Russ).
Muratovich, M. M., Abduvakilovich, M. A., & Tolibovich, Y. J. (2021). Assessment of the degree of preservation of coronary reserves in pregnant women with mitral stenosis. Central Asian Journal of Medical and Natural Science, 2(1), 20-23.
Muratovich, M. M., Abduvakilovich, M. A., & Tolibovich, Y. J. (2021). Assessment of the degree of preservation of coronary reserves in pregnant women with mitral stenosis. Central Asian Journal of Medical and Natural Science, 2(1), 20-23.
Pardaev, S. K., Sharipov, I. L., & Yusupov, J. T. (2021). Use of combined spinal-epidural anesthesia in gynecological simultaneous operations. Academicia: an international multidisciplinary research journal, 11(2), 1508-1513.
Rizaev Jasur , Rakhimov Nodir , Kodyrov Khamidullo , Shakhanova Shakhnoza . Study of prostate cancer death by regions of the republic of Uzbekistan.Journal of Biomedicine and Practice. 2022, vol . 7, issue 5, pp.202-210
Shavkatovna S. S., Makhammatkulovich R. N. FEATURES OF SARCOPENIA IN CANCER PATIENTS //EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE. – 2024. – Т. 4. – №. 8. – С. 286-292.
Rizaev JA, Maeda H., Khramova NV Plastic surgery for the defects in the maxillofacial region after surgical resection of benign tumors //Annals of Cancer Research and Therapy. – 2019. – T. 27. – no. 1. – S. 22-23.
Rizaev Jasur , Norbutayev Alisher, Murtazayev Alisher . Modern methods for detecting oral cavity defects in hemoblastosis , detecting the degree of damage and prediction of the clinical current. Journal of Biomedicine and Practice. 2021, vol. 6, issue 5, pp. 45-51
Rakhimov, A., Negmadzhanov, B., Yusupov, J., Ganiev, F., & Akramov, B. (2018). Simultaneous operations in women. Journal Bulletin of the doctor, 1(4), 116-123. (in Russ).
Sharipov, I. L., Pardaev, S. K., & Yusupov, J. T. (2023). Features of the anesthesiological aid for gynecological operations. The journal "The Luminary of Science", 5 (4), 216-222 (in Russ).
Tolibovich, Y. J., & Muratovich, M. M. (2024). IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING. JOURNAL OF BIOMEDICINE AND PRACTICE, 9(1).(in Russ)
