THE SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN THE NEW CORONAVIRUS INFECTION COVID-19. (LITERATURE REVIEW)
Abstract
Endothelial dysfunction plays an important role in the development of many diseases and conditions, including the active phase of the new coronavirus infection COVID-19 and post-Covid syndrome. Systemic angiopathy, which is associated with endothelial dysfunction and is characterized by extensive damage to the microcirculatory system, including endotheliitis, has certain morphological manifestations that are characteristic of COVID-19. The SARS-CoV-2 virus specifically attacks goblet cells in the mucous membrane of the respiratory tract. COVID-19 progresses through diffuse alveolar damage, leading to hyaline membrane formation and pulmonary edema. This damage to the respiratory tract is caused by the effects of the SARS-CoV-2 virus on alveolar epithelial cells and endothelial cells, as well as immunological effects, including perivascular inflammation. All these factors together lead to disruption of the endothelial-epithelial barrier and the penetration of protein exudate into the alveolar space, creating a background for bacterial and fungal flora.
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Статья поступила в редакцию 10.05.2024; одобрена после рецензирования 21.06.2024; принята к публикации 29.06.2024.
The article was submitted 10.05.2024; approved after reviewing 21.06.2024; accepted for publication 29.06.2024.
Информация об авторах:
Самибаева Умида Хуршидовна- Ассистент Самаркандский государственный медицинский университет, Самарканд, Узбекистан. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981, +998902705686.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Самибаева У.Х. — идеологическая концепция работы, написание текста; редактирование статьи; сбор и анализ источников литературы, написание текста.
Information about the authors:
Information about the authors:
Samibaeva Umida Khurshidovna - Assistant, Samarkand State Medical University, Samarkand, Uzbekistan. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981, +998902705686.
Sources of funding: The work did not have special funding.
Conflict of interest: The author declares that there are no obvious or potential conflicts of interest related to the publication of this article.
Authors' contributions:
Samibaeva U.Kh. — ideological concept of the work, writing the text; article editing; collection and analysis of literature sources, writing text.
