RETSIDIVLАNUVChI PLАTINА-REFRАKTER TUXUMDON SАRАTONI АSTITINI DАVOLАShDА METRONOM KIMYO TERАPIYANING SАMАRАDORLIGI
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tuxumdon saratoni, limfodissektsiya, sitoreduksiya, metastaz, platina sezgir va platinaga chidamli recidivlar##article.abstract##
Ko'p yillar davomida tuxumdon saratoni saraton kasalligidan o'limning asosiy sababi bo'lib qolmoqda. Tuxumdon saratonining IC–IV bosqichlari uchun dastlabki davolash jarrohlik sitoreduksiyani, so'ngra platina o'z ichiga olgan kimyoterapiyani o'z ichiga oladi. Eng yaxshi natijalar to'liq sitoreduksiyaga erishgan bemorlarda kuzatiladi: ko'plab mualliflar sitoreduksiyaning to'liqligi ortishi bilan bemorlarning umumiy omon qolish darajasi oshgani haqida xabar berishdi. Shunga qaramay, ko'pchilik bemorlarda kasallikning qaytalanishi rivojlanadi va uzoq muddatli davolash natijalari qoniqarsiz bo'lib qolmoqda: umumiy 5 yillik omon qolish darajasi taxminan 30% ni tashkil qiladi %. Tuxumdon saratonining qaytalanishi paytida limfa tugunlarining shikastlanish darajasi ishonchli ma'lum emas; adabiyotlarga ko'ra, bemorlarning 5–32% da ushbu lokalizatsiyaning izolyatsiya qilingan relapslari kuzatiladi. Bugungi kunga kelib, tuxumdon saratonining qaytalanishini davolashda limfodisseksiyaning ahamiyati va hajmi masalasi ochiqligicha qolmoqda. Shu munosabat bilan, ushbu maqolada biz limfa tugunlarining izolyatsiya qilingan shikastlanishi bo'lgan bemorlarda tuxumdon saratonining qaytalanishida ikkilamchi sitoreduktiv aralashuvlarning roli bo'yicha mavjud dalillarni taqdim qilmoqchimiz.
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