TUXUMDONLAR POLIKISTOZI SINDROMI BO'LGAN BEMORLARDA LETROZOL BILAN SINAMA NATIJALARINI BAHOLASH
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TPKS, fenotiplar, tuxumdon aromataza faolligi, sitoxrom P-450##article.abstract##
Ushbu maqolada O'zbekistonda tuxumdonlar polikistozi sindromi bo'lgan reproduktiv yoshdagi ayollarda letrozol bilan sinama natijalarini baholash tahlili keltirilgan. Tadqiqot maqsadi: TPKS turli fenotiplari bilan kasallangan reproduktiv yoshdagi ayollarda tuxumdonlar funktsional faolligini aromataza P450 ingibitori letrozol yordamida baholash. Materiallar va usullar : Tadqiqot davomida 41 ta TPKS ning turli fenotiplari bilan kasallangan 19 yoshdan 35 yoshgacha bulgan reproduktiv yoshdagi ayollar tekshirildi. Kasallarga TPKS va uning fenotiplarining tugri tashxisi Rotterdamdagi konsensus (2003 y) kursatmalariga binoan quyildi. Kasallarda tuxumdonlarning funktsional faolligini aniqlash va urganish maqsadida funktsional sinama utkazildi. Sinama aromataza ingibitori letrozol yordamida olib borildi. Tuxumdonlarning funktsional faolligini, ya’ni follikullalar aromataza faolligini aniqlashda quyidagi formuladan foydalanildi. Follikullarning aromataza faolligini baholash uchun formula bo'yicha quyidagi koeffitsient ishlatildi: K = DE2/AMG, bu erda K - antral tuxumdon follikullarining aromataza faolligi koeffitsienti; DE2 - letrozolni qabul qilgandan keyin 48 soat o'tgach, qon zardobida nmol / l ga estradiolning pasayishi; AMG - ng / ml da anti-Myuller gormonining qondagi miqdori Natijalar va uning muhokamasi: Tadqiqot natijalarini tahlili shuni ko'rsatadiki, TPKS bilan og'rigan bemorlarda follikullarning aromataza faolligida xilma-xillik kuzatildi : bemorlarning 21,6 foizida u normal chegaralarda edi, bemorlarning 29,6 foizida ko'tarildi, bemorlarning 48,8 foizida pasaydi. Follikullarning aromataza faolligiga qarab, turli xil TPKS fenotiplari bo'lgan bemorlar uchta guruhga bo'lindi: past, o'zgarmagan va yuqori aromataza faolligi. Xulosa:Tadqiqot natijalari tuxumdonlar polikistoz sindromida sitoxrom p-450 aromataza fermentining turli xil faollik darajasini kursatdi. Tuxumdon aromatazasining nisbiy etishmovchiligi kasallikning fenotipiga qarab turli chastotalarda aniqlanishi mumkin
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