O‘SMIRLIK DAVRIDAGI OLIGOMENOREYADA TUXUMDONLAR ZAHIRASINI KAMAYTIRISHDA YALLIG‘LANISHGA QARSHI SITOKINLARNING O‘RNI
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oligomenoreya, o'smir qizlar, tuxumdonlar zaxirasi, sitokinlar, tuxumdon etishmovchiligi##article.abstract##
Oligomenoreya tuxumdonlar faoliyatining buzilishidan kelib chiqqan bir qator kasalliklar va patologik holatlarning alomatidir. O'smirlik davrida idyopatik oligomenoreya bir qator jiddiy kasalliklar va kasalliklarning, xususan, tuxumdonlarning surunkali etishmovchiligi sifatida namoyon bo'ladigan va tuxumdonlarning erta etishmovchiligiga olib keladigan erta tuxumdon etishmovchiligining (POF) prognozi bo'lishi mumkin.
Maqsad idyopatik oligomenoreya bilan og'rigan o'smirlarda tuxumdonlar zahirasini kamaytirishda yallig'lanishga qarshi sitokinlarning rolini aniqlash edi.Oligomenoreya bilan og'rigan 104 nafar o'smir qizlar tekshirildi, normogonadotropik oligomenoreya tuzilmalari aniqlandi. Idiopatik oligomenoreya bilan kasallangan guruh aniqlandi (n = 17). Yallig'lanishga qarshi sitokinlarning (IL-1, IL-6, TNF-a) idyopatik oligomenoreya bilan og'rigan o'smirlarda tuxumdonlar zaxirasining pasayishiga ta'siri aniqlandi. Tuxumdon zahiraviy markerining (AMH) qiyosiy tahlili idyopatik oligomenoreya bilan og'rigan bemorlarda sezilarli pasayish ko'rsatdi. IL-6/AMH indeksi oligomenoreya bilan og'rigan o'smirlar orasida tuxumdonlar zahirasini kamaytirish uchun xavf guruhini aniqlash uchun ishlab chiqilgan.
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