JARROHLIK TUG‘RUQDA KVANADEKS BILAN SPINAL ANESTEZIYANI AMALGA OSHIRISHNING KLINIK-FIZIOLOGIK XUSUSIYATI
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Kvanadeks, Longokain Xevi, spinal anesteziya, Reosorbilakt, interleykin-6, markaziy gemodinamika, α2-adrenoretseptor##article.abstract##
Ushbu tadqiqotning maqsadi, 0,5% Longokain Xevi eritmasiga ad'yuvant sifatida Kvanadeks preparatining jarrohlik tug‘ruq amaliyotida uning klinik–fiziologik xususiyatlariga ta'siri, samaradorligi va neonatal yakunlarini o‘rganish bo‘lgan edi. Og‘ir ekstragenital patologiyasi bo‘lmagan, ASA bo‘yicha jismoniy statusi II daraja bo‘lgan 189 nafar ayollarda prospektiv ikki tomondan yopiq randomlashtirilgan nazorat qilinadigan klinik tadqiqot o‘tkazildi. I-guruhni tashkil qilgan homilador ayollarga intratekal tarzda 0,5% Longokain Xevi preparatining giperbarik eritmasi kiritilgan, II-guruhdagi ayollarga 0,5% Longokain Xevi preparatining giperbarik eritmasi va 6 mkg Kvanadeks kiritilgan. Spinal in'ektsiyadan avval 3–5 ml/kg miqdorida Reosorbilakt balanslashtirilgan polielektrolitli giperosmolyar eritmasi bilan tomir ichiga infuziya qilingan. Tadqiqot davomida ayollarda markaziy gemodinamika, VNS, interleykin-6 darajasi, yangi tug‘ilgan chaqaloqlar Apgar shkalasi bo‘yicha 1-daqiqada va 5-daqiqada baholangan. Tadqiqot shuni ko‘rsatdiki, α2-adrenoretseptorlarning yuqori selektiv agonist vositasi bo‘lgan Kvanadeksdan 0,5% Longokain Xevi eritmasiga ad'yuvant sifatida foydalanish, gemodinamika va VNS ko‘rsatkichlariga jiddiy ta'sir ko‘rsatmagan holda, sensor-motorik blokadaning yuzaga kelishini tezlashtiradi va uzoqroq sensor-motorik blokadani ta'minlaydi, anesteziologik va jarrohlik stressini sezilarli kamaytiradi va neonatal moslashuv davrida yangi tug‘ilgan chaqaloqlarga depressiv ta'sir ko‘rsatmaydi.
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