EREKTIL DISFUNKSIYANI DAVOLASHDA TRIBULUS TERRESTRIS PREPARATLARI: ULAR QANCHALIK SAMARALI?
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Tribulus terrestris, erektil disfunktsiya, steroid saponinlar.##article.abstract##
Ushbu adabiyotlar sharhida Tribulus terrestris dorivor o'simligining erektil disfunktsiya farmakoterapiyasida qo'llanilishi bo'yicha ma'lumotlar keltirilgan. Tribulus terrestris Ayurveda va Xitoy tibbiyotida erektil disfunktsiya, erkaklar bepushtligi va siydik yo'llari kasalliklarini davolash uchun afrodizyak va tetiklashtiruvchi sifatida ishlatilgan. Ushbu sharhda Tribulus terrestrisning erektil disfunktsiyada ta'sir mexanizmlarini, tarkibini va qo'llanilish doirasini tavsiflagan eksperimental, klinik va farmakologik tadqiqotlar natijalari umumlashtirilgan.
Библиографические ссылки
Shodmonova, Z. R., Gafarov, R. R., Allazov, S. A., & Giyasov, S. I. (2021). PHOSPHODESTERASE TYPE 5 INHIBITORS-CLINICAL EFFICIENCY AND ROLE IN THERAPY FOR ERECTILE DYSFUNCTION. Urologiia, (2), 135-140.
Гафаров Рушен Рефатович, Шодмонова Зебунисо Рахимовна, Аллазов Салах Аллазович, Хамроев Гулом Абдуганиевич, Тухтаев Фирдавс Мухиддинович Ингибиторы фосфодиэстеразы 5 типа – первая линия терапии эректильной дисфункции // Достижения науки и образования. 2020. №5 (59).
Umarova, G., & Komilov, K. (2025). STUDYING THE ELEMENT COMPOSITION OF DRY EXTRACT FROM TRIBULUS TERRESTRIS L. Евразийский журнал академических исследований, 5(10(MPHAPP), 310–311.
Do J, Choi S, Choi J, Hyun JS. Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection. Korean J Urol. 2013 Mar;54(3):183-8. doi: 10.4111/kju.2013.54.3.183. Epub 2013 Mar 15. PMID: 23526694; PMCID: PMC3604572.
Vladimir Neychev and Vanyo Mitev, Pro-sexual and Androgen Enhancing Effects of Tribulus terrestris L.: Fact or Fiction, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.12.055
Tomowa MP, Panowa D, Wulfson NS. Steroidsaponine und Steroidsapogenine. IV. Saponine aus Tribulus terrestris [Steroid saponines and sapogenins. IV. Saponines from Tribulus terrestris (author's transl)]. Planta Med. 1974;25(3):231-237. doi:10.1055/s-0028-1097936
Zarkova, S. (1976). Morphological and histological changes in testes of rat under the effect of TB-68, Med. N, 4, 49-53.
Dinchev D, Janda B, Evstatieva L, Oleszek W, Aslani MR, Kostova I. Distribution of steroidal saponins in Tribulus terrestris from different geographical regions. Phytochemistry. 2008 Jan;69(1):176-86. doi: 10.1016/j.phytochem.2007.07.003. Epub 2007 Aug 23. PMID: 17719068.
Sansalone S, Leonardi R, Antonini G, Vitarelli A, Vespasiani G, Basic D, Morgia G, Cimino S, Russo GI. Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study. Biomed Res Int. 2014;2014:121396. doi: 10.1155/2014/121396. Epub 2014 Jul 20. PMID: 25136552; PMCID: PMC4127274.
Vilar Neto JO, de Moraes WMAM, Pinto DV, da Silva CA, Caminha JSR, Nunes Filho JCC, Reis CEG, Prestes J, Santos HO, De Francesco Daher E. Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men-A Systematic Review of Clinical Trials. Nutrients. 2025 Apr 6;17(7):1275. doi: 10.3390/nu17071275. PMID: 40219032; PMCID: PMC11990417.
Ștefănescu R, Tero-Vescan A, Negroiu A, Aurică E, Vari CE. A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L. Biomolecules. 2020 May 12;10(5):752. doi: 10.3390/biom10050752. PMID: 32408715; PMCID: PMC7277861.
Semerdjieva IB, Zheljazkov VD. Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review. Natural Product Communications. 2019;14(8). doi:10.1177/1934578X19868394
Zhang X, Guo Z, Li J, Ito Y, Sun W. A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study. Steroids. 2016 Feb;106:62-9. doi: 10.1016/j.steroids.2015.12.009. Epub 2015 Dec 17. PMID: 26703445; PMCID: PMC4921743.
Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine. 2008 Jan;15(1-2):44-54. doi: 10.1016/j.phymed.2007.11.011. PMID: 18068966.
GamalEl Din SF, Abdel Salam MA, Mohamed MS, Ahmed AR, Motawaa AT, Saadeldin OA, Elnabarway RR. Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. Urologia. 2019 May;86(2):74-78. doi: 10.1177/0391560318802160. Epub 2018 Sep 25. PMID: 30253697.
Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017 May;99:20-26. doi: 10.1016/j.maturitas.2017.01.011. Epub 2017 Feb 12. PMID: 28364864.
Roaiah MF, Elkhayat YI, Abd El Salam MA, Din SFG. Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained Infertility. J Diet Suppl. 2017 Jan 2;14(1):25-31. doi: 10.1080/19390211.2016.1188193. Epub 2016 Jun 23. Erratum in: J Diet Suppl. 2018 Nov 2;15(6):1014. doi: 10.1080/19390211.2018.1459390. PMID: 27337519.
Santos HO, Cadegiani FA, Forbes SC. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review. Clin Ther. 2022 Aug;44(8):1129-1149. doi: 10.1016/j.clinthera.2022.06.006. Epub 2022 Jul 7. PMID: 35810031.
Huff R, Karpinska-Leydier K, Maddineni G, Begosh-Mayne D. Rhabdomyolysis Risk: The Dangers of Tribulus Terrestris, an Over-the-Counter Supplement. Am J Case Rep. 2024 Jul 16;25:e943492. doi: 10.12659/AJCR.943492. PMID: 39012853; PMCID: PMC11315611.
