HAYZ BILAN BOG‘LIQ TEMIR TANQISLIK ANEMIYASIDA PLASENTA-HOMILA TIZIMIDAGI I BUZILISLARHINING PATOMORFOLOGIK MEZONLARI
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anemiya, temir tanqisligi anemiyasi, homiladorlik, ko‘p miqdordagi hayz ko‘rish, anormal bachadon qon ketishlari, FIGO, plasentar yetishmovchilik, temir tanqisligi, ona va homila salomatligi##article.abstract##
Temir tanqisligi anemiyasi (TTA) reproduktiv yoshdagi ayollarda, ayniqsa homiladorlarning 40% dan ko‘prog‘ida uchraydigan kasallik bo‘lib, bugungi kunda global tibbiy muammo hisoblanadi. Temir nafaqat gemopoez jarayonida, balki hujayra nafas olishi, ferment tizimlari faoliyati, angiogenez va homila asab to‘qimasining mielinizatsiya jarayonlarida ham muhim ahamiyatga ega. Homiladorlik davrida temirga ehtiyoj sezilarli darajada ortib, bu esa temir tanqisligi holatlari rivojlanishi, plasentar yetishmovchilik va homiladorlik asoratlari kelib chiqishi xavfini oshiradi. Ayniqsa, ko‘p miqdorda hayz ko‘rish bilan bog‘liq surunkali temir tanqisligi anemiyasi mavjud ayollarda "ona–yo‘ldosh–homila" tizimidagi patomorfologik o‘zgarishlarni o‘rganish dolzarb hisoblanadi. Biz o‘tkazgan tadqiqotda kindirik tomirlarining strukturasidagi ifodalangan patologik o‘zgarishlar aniqlandi: ishemiya, skleroz va endoteliy arxitektonikasining buzilishlari kuzatilib, bu o‘zgarishlar yorug‘lik va elektron mikroskopiya orqali tasdiqlandi. Tomirlarning endotelial hujayralarida alterativ o‘zgarishlar, normal mikrorelyefning yo‘qolishi va destruktiv jarayonlar qayd etilib, ular moddalar almashinuvi va tomir perfuziyasining jiddiy buzilishlaridan dalolat beradi.
Aniqlangan morfologik o‘zgarishlar fetoplatsentar tizimning funksional holatiga sezilarli ta’sir ko‘rsatib, fetoplatsentar yetishmovchilik, homilaning bachadon ichida o‘sishdan orqada qolishi va boshqa perinatal asoratlar xavfini oshiradi. Bu o‘zgarishlarning aniqlanishi prognostik ahamiyat kasb etadi va reproduktiv yoshdagi ayollarda temir tanqisligi holatlarini o‘z vaqtida tashxislash va korreksiya qilish zaruratini ta’kidlaydi.
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