COVİD-19 PANDEMYASI DAVRIDAGI BOLALARDA RENAL ASORATLARDA SITOKIN SPEKTRINING DIAGNOSTIK ASPEKTLARI
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COVID-19, o'tkir pielonefrit, siydik sitokin profili##article.abstract##
Og'ir o'tkir respirator sindromli koronavirus 2 (SARS-CoV-2) barcha organlarga, shu jumladan buyraklarga ta'sir qilishi mumkin bo'lgan pediatriyani global muammosidir. Tadqiqot maqsadi COVID-19 fonida rivojlangan oʻtkir pielonefritli bolalarning qon zardobi va siydikida sitokin profilining xususiyatlarini aniqlash va baholashdan iborat edi. Usullari. Ishtirokchilarni guruhlarga tanlash anamnezda COVID-19 mavjudligiga qarab davolash boshlanishidan oldin amalga oshirildi: 1-guruhga COVID-19 boʻlmagan 30 nafar oʻtkir piyelonefritli (O’P) bolalar, 2-guruh -COVID-19 fonida OʻP bo'lgan 35 bemor kiritilgan. Qon zardobi va siydikning sitokin profili IL-4, IL-6, TNF-a va IFN-y sitokinlarini o'rganish asosida o'rganildi. Natijalar. Faol jarayon siydikda IL-4, TNF-a va INF-g ning sezilarli darajada ortishi bilan birlashtirildi. 1-guruhdagi bemorlarda TNF-a darajasi nazorat guruhi darajasiga nisbatan to'rt marta, INF-y darajasi esa o'n bir marta, 2-guruhdagi bolalarda esa bu darajalar etti va o'n besh martadan oshib ketgan va mos ravishda 83, 49±2,66 va 205,26±3,32 pg/ml (p≤0,001) ni tashkil etdi. Munozara. Tahlil natijalari shuni ko'rsatadiki, IL-6 tubulointerstitial shikastlanishning rivojlanishida tajovuzkor omil sifatida muhim rol o'ynaydi, siydikda uning darajasi 1-kichik guruh bolalarida 31,2 marta va 2-kichik guruh bemorlarida 38,5 baravar ko'paygan. sog'lom bolalarda ko'rsatkichlar (nazorat guruhi). Xulosa. COVID-19 bilan kasallangan bemorlarda tubulaning yashirin shikastlanishi (skrining tekshiruvi) jarayonini kuzatish uchun sitokinlar (IL-6, INF-y, TNF-a, IL-4) darajasini o'rganish kerak. qon zardobi va siydik, buning asosida buyraklarning tubulointerstitial to'qimalarida proliferativ o'zgarishlar darajasini aniqlash va jarayonning surunkaliligiga ko'ra bemorlarning xavf guruhlarini shakllantirish mumkin.
Библиографические ссылки
renal complications in children during the COVID-19 pandemic: An observational cohort retrospective clinical study. Kuban Scientific Medical Bulletin. Volume 30, No. 3, 2023. p. 25–33.
2. Ismailova Z.A. Comparative assessment of renal complications in children during the COVID-19 pandemic. Abstract of Cand. Sci. (Medicine) Dissertation / Z.A. Ismailova. Samarkand, 2024. - 59 p., . Ismailova Z.A. Comparative assessment of renal complications in children during the COVID-19 pandemic. Abstract of Cand. Sci. (Medicine) Dissertation / Z.A. Ismailova. Samarkand, 2024. – p. 59.
3. Kiseleva A. V., Leskova A. V., Skvortsov V. V. Kidney pathology in patients with COVID-19. Doctor. 2022; 9 (25): 19–23. DOI: 10.51793/OS.2022.25.9.003. Kiseleva A.V., Leskova A. V., Skvortsov V. V. Kidney pathology in COVID-19 patients. Lechaschi Vrach. 2022; 9 (25): 19–23. DOI: 10.51793/OS.2022.25.9.003.
Morozov Dmitry, Morozova Olga, Budnik Ivan, Pervouchine Dmitri, Pimenova Evgeniya, Zakharova Natalya. Urinary cytokines as markers of latent inflammation in children with chronic pyelonephritis and anorectal malformations // Journal of Pediatric Urology. – 2016. Р. 1-15.
Robbins-Juarez SY, Qian L, King KL, Stevens JS, Husain SA, Radhakrishnan J, et al. Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis// Kidney Int Reports [Internet]. 2020; 5(8):1149–60. Available from: https://doi.org/10.1016/j.ekir.2020.06.013.
Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies // Nat Rev Nephrol. 2020; 16(6): 308–10.
Seok Hui Kang, Sang Won Kim, A Young Kim, Kyu Hyang Cho, Jong Won Park and Jun Young Do. Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients. J Korean Med Sci. 2020 Dec 28;35(50): 434. р.9. DOI.org/10.3346/jkms.2020.35. e434 eISSN 1598-6357·pISSN 1011-8934.
Shaikh N. Recurrent urinary tract infections in children with bladder and bowel dysfunction. Pediatrics. – 2016. – V. 137. – №. 1. – Р. 20152982.
Shen Q., Wang M., Che R., Li Q., Zhou J., Wang F. et al. Consensus recommendations for the care of children receiving chronic dialysis in association with the COVID-19 epidemic // Pediatr Nephrol. 2020; 35(7): 1351-1357.
Su H, Yang M, Wan C, Yi L, Tang F, Zhu H,et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020; 98(1): 219–27.
Stewart DJ, Hartley JC, Johnson M, Marks SD, du Pré P, Stojanovic J. Renal dysfunction in hospitalised children with COVID-19. The Lancet. Child & adolescent health. Vol. 4, 2020. p. 28–9.
Tantisattamo E., Dafoe D.C., Reddy U.G., Ichii H., Rhee C.M., Streja E., Landman J., Kalantar-Zadeh K. Current Management of Acquired Solitary Kidney. Kidney International Reports. 2019; 4(9): 1205–1218.
Tramma D., Hatzistylianou M., Gerasimou G., Lafazanis V. Interleukin-6 and interleukin-8 levels in the urine of children with renal scarring. Pediatr Nephrol. –2012. № 27. Р.1525–1530.
