ORTIQCHA VAZNLI O'SMIR QIZLARDA HAYZ SIKLI BUZILISHINING YALLIG'LANISHGA HOS VA ADIPOTSITAR BELGILAR KO'RSATKICHILAR SIFATIDA
##article.subject##:
qizlar, o'smirlar, hayz davri, qon zardobi, sitokinlar, adipokinlar, muvozanat##article.abstract##
Maqsad: ortiqcha vaznli o'smir qizlarda adipokinlar va yallig'lanishga hos sitokinlarning qon zardobidagi darajasini va ularning hayz davrining buzilishining rivojlanishidagi rolini aniqlash. Material va usullar. Tadqiqotda 50 nafar o'smir qizlar ishtirok etdi, ularning asosiy guruhiga 25 nafar ortiqcha vaznli qizlar kiradi. Nazorat guruhiga normal tana vazniga ega 25 qiz kiritilgan. Qon zardobida yallig'lanishga xos va yallig'lanishga qarshi sitokinlarning darajasini IFT usuli yordamida amalga oshirildi. Natijalar. Adipokin nomutanosibligi va yallig’lanishga xos sitokinlarning yuqori darajalari ortiqcha vaznli o'smirlarda hayz ko'rish disfunktsiyasi bilan bog'liq ekanligi aniqlandi. O'rganilgan ko'rsatkichlar hayz davrining buzilishining muhim prognostik belgiligi deb hisoblanani mumkin.
Библиографические ссылки
Abdelmoty H., Youssef M., Abdallah S., et al. Menstrual pattern and disorders among secondary school adolescents in Egypt. A cross-sectional review. BMC Womens Health. 2015; Vol. 15: 70. doi: 10.1186/s12905-015-0228-8
Agarval Anil, Agarval Anju. A study of dysmenorrhea during menstruation in adolescent girls. Indian J Community Med. 2018; Vol. 35 (1): 159–64.
Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2021; 11:372–377.
Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J. 2022; 16:1335–1347.
Grigoryan O.R., Andreyeva Ye.N. Ozhireniye i reproduktivnaya funktsiya // Trudnyy patsiyent. - 2018. - T. 9 (№ 8-9). - S. 21-24.
Hivert MF, Sullivan LM, Fox CS, Nathan DM, D’Agostino RB, Sr., Wilson PW, Meigs JB. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab. 2018; 93:3165–3172.
Immunologiya: struktura i funktsii immunnoy sistemy. uchebnoye posobiye/ R.M.Khaitov. – M.: GEOTAR-Media, 2013 – 230s.
La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2018; 4:371–379.
Yalfimova Ye.A., Kutusheva G.F. Mediko-sotsial'nyye faktory, okazyvayushchiye vliyaniye na narusheniye menstrual'noy funktsii u devushek-podrostkov s izbytochnoy massoy tela // Pediatr. - 2015. - №1. - S. 71-75.
