O‘SISH OMILLARINING REGULYATSIYASINING BUZILISHI VA PLATSENTAR DISFUNKTSIYASI
##article.subject##:
homiladorlik, platsenta disfunktsiyasi, sitokinlar, qon tomirlarining o‘sish omillari, angiogenez, qon zardobi, disbalans##article.abstract##
Maqsad: platsenta disfunktsiyasi (PD )bo‘lgan ayollarda qon zardobida o‘sish omillarini o‘rganish. Materiallar va usullar. Tadqiqotda homiladorlik muddati 26-40 hafta, platsenta disfunktsiyasi tashxisi qo‘yilgan, 47 homilador ayol ishtirok etdi, ular Toshkent shahridagi 3-sonli shahar tug’ruq markazining akusherlik bo‘limida kuzatilgan. Qon zardobining o‘sish omillarini aniqlash IFA usuli bilan amalga oshirildi. Natijalar.26-40 xaftalik homiladorlik davrida PD bilan kasallangan homilador ayollarda o‘sish omillari va qon tomir faoliyatida disregulyatsiya borligi aniqlandi, bu periferik qon zardobida VEGF-A va PlGF darajasining pasayishi, shuningdek sFlt-1 darajasining oshishi bilan namoyon bo‘ladi. Ushbu o‘zgarishlar sFlt-1 va PlGF nisbatlarining aniq muvozanatiga olib keladi, bu platsenta funktsiyasining yomonlashishiga sabab bo‘ladi va bu patologik holatning rivojlanishi bilan bog’liq.
Библиографические ссылки
Dennert I., Plaisier M., Rost E. et al. Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum. Reprod. 2019 Jan; 24 (1): 185-97
Dias S., Shmelkov S.V., Lam G., Rafii S. VEGF (165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood. 2022 Apr. 1; 99 (7): 2532-40
Forbes K., Westwood M. Maternal growth factor regulation of placental development and fetal growth. Journal of Endocrinology, 2010; 207: 1-16
Makarov O.V., Volkova Ye.V., Lysyuk Ye.YU., Kopylova YU.V. Fetoplatsentarnyy anagiogenez u beremennykh s platsentarnoy nedostatochnost'yu // Akusherstvo, ginekologiya, reproduktsiya – 2013 – T.7 – №3 –S.13-19. [in Russ.].
Maynard S.E., Min J.Y., Merchan J. et al. Excess placental soluble fms-like tyrosine kinase 1 (sFltl) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2023; 111: 649-658.
Sidorova I.S., Milovanov A.P., Borovkova Ye.I., Solonitsyn A.N. Immunogistokhimicheskaya kharakteristika raspredeleniya faktora rosta endoteliya sosudov v platsente, platsentarnoy lozhke matki pri beremennosti i u zhenshchin s preeklampsiyey. Arkhiv prirody. 2018; 1: 12-15 [in Russ.].
Strizhakov A.N., Timokhina T.F., Bayev O.R., Rybin M.V. Vybor metoda rodorazresheniya v snizhenii perinatal'nykh poter'. Akusherstvo i ginekologiya. 2020; 5:8-12 [in Russ.].
