SUMMARTY MAIN CAUSES OF POLYCYSTIC OVARIAN SYNDROME IN WOMEN OF REPRODUCTIVE AGE
Keywords:
Polycystic ovary syndrome, hyperandrogenism, menstrual disorders, hirsutismAbstract
Purpose of the study: in this study, we set the goal to study the relationship between anamnestic, clinical, hormonal and ultrasound studies, demographic status, as well as hormonal disorders, body weight and blood insulin levels in patients with polycystic ovary syndrome.
Material and methods of research: a prospective study describing these processes was carried out. Among women aged 15 to 45 years who applied to the Abu Ali Sino Balkh Teaching Clinic in Mazar-i-Sharif, 80 patients with polycystic ovary syndrome were examined. Demographic data was recorded in all patient questionnaires, after which the questionnaire was completed.
Hormonal tests (prolactin (Prl), hydroxyprogesterone-17 (OHP-17), insulin, testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), glucose tolerance - TG) were performed by radioimmunoassay and patients were examined by ultrasound. To study the relationship between body weight, blood insulin levels and hyperandrogenism, patients were divided into obese and non-obese groups (body mass index BMI>30 and BMI<30), as well as the presence of signs of functional hyperandrogenism (FH)), divided into two groups. groups - FG positive and FG negative. For statistical analysis, Kruskal-Wallis and Mann-Whitney statistical tests were used.
Results of the study: the most common clinical manifestations: menstrual disorders (100%), genetic factor (6.5%), hirsutism (62%) and obesity (25%). The most common hormonal disorders were: increased testosterone levels (32.5%), LH/FSH ratio >2 (25%), insulin resistance (12.2%), impaired glucose tolerance (TG) (17.5%), hyperinsulinism (respectively) 10%). Ultrasound examination did not give an accurate result in 18.7% of cases.
Conclusion: Given that the clinical features of PCOS can be identified by clinical signs and that laboratory tests play no role in the diagnosis of rare diseases such as hypothyroidism and hyperlactinemia, these tests should be limited to individual patients.
On the other hand, since side effects such as high blood insulin levels, insulin resistance and high blood pressure are directly related to obesity and hypoandrogenism in this group of people, individuals with symptoms of obesity and hyperandrogenism should be removed to take special treatment measures.
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