PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN
Keywords:
: post-COVID complications, acute pyelonephritis, tubulointerstitial lesions, KIM-1, NGAL, β₂-microglobulin, γ-GT.Abstract
The COVID-19 pandemic has revealed previously unrecognized clinical features of infectious and inflammatory kidney diseases in pediatric patients. Objective: To determine the significance of tubuloglomerular abnormalities biomarkers (γ-GT, β2M, NGAL, KIM-1) in clinical and laboratory diagnostics in children with acute pyelonephritis after COVID-19. Methods. The study included 100 children with clinically and laboratory-confirmed acute pyelonephritis. The control group consisted of 25 apparently healthy children, matched for age and gender. Results. The study results revealed a statistically significant increase in urinary γ-GT, KIM-1, NGAL, and β₂-microglobulin concentrations compared to the control group. In patients in the first group, γ-GT levels were 4.57 times higher than the control group, KIM-1 levels were 3.77 times higher, NGAL levels were 25.96 times higher, and β₂M levels were 7.64 times higher. Conclusion. Determining the concentrations of these parameters allows us to identify early signs of tubulointerstitial damage, assess the activity of the pathological process in the renal tubular apparatus, and identify risk groups for chronic pyelonephritis.
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