THE ROLE OF ANTITIPOXANS IN CORRECTING ACID BASE STATE IN THE BLOOD IN INFANTS BORN WITH CHRONIC HYPOXIA
Keywords:
asphyxia, newborns, cerebroprotector, CytoflavinAbstract
The primary cause of hypoxic-ischemic brain injury is widely recognized as the restriction of both oxygen supply and essential oxidative substrates necessary for cellular function. This understanding is supported by existing research ([3,4]). The most critical damage to brain cells occurs 2-6-48 hours after birth due to oxidative stress. This process is triggered by the resumption of blood flow to the brain following a period of oxygen deprivation (perfusion deficit). The reintroduction of highly oxygenated blood leads to an overproduction of harmful free radicals, contributing to cell damage.
A study involving 60 premature infants who experienced asphyxia during birth was conducted at the Samarkand Regional Perinatal Centre and the Neonatal Intensive Care Unit of the Samarkand Multidisciplinary Children's Research Medical Centre. These infants were closely monitored to observe the effects of oxidative stress on brain tissue.
References
Bakhronovna K. F. THE SIGNIFICANCE OF CLINICAL AND LABORATORY CRITERIA IN THE EARLY . DIAGNOSIS OF POSTHYPOXIC COMPLICATIONS IN NEWBORNS BORN WITH HYPOXIA //World of Scientific news in Science. – 2024. – Т. 2. – №. 3. – С. 258-263.
Fayzullayeva X. B., Nazarova G. S., Kim O. V. Biochemical Changes in Newborns with Intrauterine Hypoxia Born by Caesarean Section //SCHOLAR. – 2023. – Т. 1. – №. 29. – С. 173-181.
Lavrick SY, Shprakh VV, Domitrak SV, Borisov AS. Primenenie tsitoflavina u detei doshkol'nogo i rannego shkol'nogo vozrasta s posledstviyami perinatal'nykh gipoksicheskikh porazhenii tsentral'noi nervnoi sistemy [Cytoflavin in the treatment of preschool and early school age children with the consequences of perinatal hypoxic brain damages]. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(10):34-37. Russian. doi: 10.17116/jnevro201611610134-37. PMID: 27845313.
Nuriddinovna S. K., Mukhiddinovna T. M., Fayzullaevna U. M. Effectiveness of immunization of frequently sick children in the treatment of respiratory diseases //Central Asian Journal of Medical and Natural Science. – 2021. – Т. 2. – №. 1. – С. 103-106.
Raju Tonse N.K., Ariagno R.L., Higgins R. et al. Research in Neonatology for the 21st Century: Executive Summary of the National Institute of Child Health and Human Development—American Academy of Pediatrics Workshop. Part I: Academic Issues. Pediatrics 2005; 115: 468—474
Salikhova KS, Agzamhodjayeva BU, Abdurahmanova FR, Ishniyazova ND, Salikhova SM. Neiroprotektivnoe deistvie Tsitoflavina pri lechenii nedonoshennykh novorozhdennykh s gipoksicheski-ishemicheskoi entsefalopatiei [Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(9):68-72. Russian. doi: 10.17116/jnevro202412409168. PMID: 39435779.
Strukov VI, Maksimova MN, Kuptsova TA, Lysev SF, Shcherbakova YG. [Efficacy of cytoflavin in the treatment of hypoxic-ischemic lesions of the nervous system in 1-month old children with transient neonatal hypothyroidism]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(10):17-20. Russian. doi: 10.17116/jnevro201511510117-20. PMID: 26525615.
Skripchenko NV, Egorova ES. [Cytoflavin in the complex treatment of neuroinfections in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(9):28-31. Russian. PMID: 22027666.
Ковальчук В.В., Зуева И.Б., Нестерин К.В., Верулашвили И.В., Кортушвили М.Г. Применение препарата цитофлавин в неонатологии и педиатрии как фактор повышения эффективности терапии пациентов с поражением центральной нервной системы различной этиологии // Журнал неврологии и психиатрии им. C.C. Корсакова. 2018. №118(5-2). С 46-50. DOI: 10.17116/jnevro20181185246.
Лазарев В.В., Гадомский И.В. Сукцинатсодержащие препараты в структуре терапевтических средств у больных в неотложных состояниях (Обзор литературы) // Российский вестник детской хирургии, анестезиологии и реаниматологии. 2016. № 6 (3). С. 111-116.
Кирьяков К.С., Хатагова Р.Б., Тризна Е.В., Зеленина З.А., Яковлев А.В., Петрова Н.А. Коррекция кислотно-основного состояния при гипоксически-ишемическом поражении головного мозга у новорожденных // Российский вестник перинатологии и педиатрии. 2018. № 63 (1). С. 40-45.
Савченко О.А., Павлинова Е.Б., Мингаирова А.Г., Власенко Н.Ю., Полянская Н.А., Киршина И.А. Оценка эффективности комплексной терапии перинатальных заболеваний новорожденных с экстремально низкой массой тела // Антибиотики и химиотерапия. 2019. №64 (1-2). С. 20-25. DOI: 10.24411/0235-2990-2019-10004
