SURUNKALI UGLEROD OKSIDI TA’SIRIDA YUZAGA KELGAN QIZILO‘NGACH SHIKASTLANISHIDAGI SILYBUM MARIANUM VA CARTHAMUS TINCTORIUSNING SINERGETIK TA’SIRINING MORFOLOGIK VA MORFOMETRIK MEZONLARI
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carbon monoxide; chronic hypoxia; esophagus; Silybum marianum; Carthamus tinctorius; synergy; morphology; immunohistochemistry; Ki-67; Bcl-2; proliferation; apoptosis; phytocorrection##article.abstract##
Tadqiqotning maqsadi Silybum marianum va Carthamus tinctoriusning sinergik ta’sirining samaradorligini uglerod oksidining surunkali ta’siri ostida yuzaga keladigan qizilo‘ngach shikastlanishlarida baholashdan iborat edi. Tajriba oq kalamushlarda CO ning subtoksik dozasi orqali surunkali gipoksiya modeli yaratildi. Baholash morfologik tekshiruv va ikki immunogistokimyoviy marker — proliferatsiya (Ki-67) va apoptoz (Bcl-2) ekspressiyasini aniqlashni o‘z ichiga oldi. CO ning surunkali ta’siri epiteliyning buzilishi, mikrotsirkulyatsiya yetishmovchiligi, yallig‘lanish kuchayishi va Bcl-2 ekspressiyasining pasayishi hamda Ki-67 ning ortishi bilan namoyon bo‘ldi. Silybum marianum va Carthamus tinctorius qo‘llanilganda shilliq qavatning qisman tiklanishi, proliferativ faollikning kamayishi va Bcl-2 ekspressiyasining normallashuvi kuzatildi. Eng yuqori terapevtik samaradorlik ularning kombinatsiyalangan qo‘llashida qayd etildi, bu sinergik himoya ta’sirining mavjudligini tasdiqlaydi.
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