HISTOLOGICAL ALTERATIONS IN THE COLON FOLLOWING EXPERIMENTAL ANESTHESIA
Keywords:
Anesthesia, volatile anestheticsAbstract
This research focused on exploring the structural changes occurring in the large intestine after anesthesia exposure using an experimental rat model. Although anesthetics are routinely employed in surgical practices, their impact on intestinal structure has not been fully clarified. In a controlled study involving 48 laboratory rats, three widely used anesthetic agents— isoflurane, sevoflurane, and propofol—were administered in clinically relevant doses to assess their histopathological impact on colonic tissues. Tissue samples were obtained at specific time points (3, 6, 12, and 24 hours after anesthesia) and underwent thorough histological evaluation. These results offer new perspectives on the possible pathways contributing to post-surgical intestinal dysfunction and underscore the importance of anesthetic type and exposure duration in procedures where intestinal health is critical. The findings enhance our understanding of gastrointestinal complications linked to anesthesia and provide practical guidance for anesthetic selection in abdominal surgery settings.
References
GussenhovenR., WesterlakenR. J., OpheldersD., JobeA. H., KempM. W., KallapurS. G.Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. J.Neuroinflammation. 2018;15:113.
HartelC., HartzA., PagelJ., RuppJ., SteinA., KribsA.NOD2loss-of-function mutations and risks of necrotizing enterocolitis or focal intestinal perforation in very low-birth-weight infants. J.Inflamm BowelDis. 2016. 22(2):249–56.
MerharS. L., RamosY., Meinzen-DerrJ., Kline-FathB. M.Brain magnetic resonance imaging in infants with surgical necrotizing enterocolitis or spontaneous intestinal perforation versus medical necrotizing enterocolitis.J.Pediatr. 2014;164:410.
SmithP. L., HagbergH., NaylorA. S., MallardC.Neonatal peripheral immune challenge activates microglia and inhibits neurogenesis in the developing murine hippocampus. J.Dev Neurosci. 2014; 36:119–31.
StrunkT., InderT., WangX. Y., BurgnerD., MallardC., LevyO.Infection-induced inflammation and cerebral injury in preterm infants.J.Lancet InfectDis. 2014; 14:751–62.
Van VlietE. O., de KievietJ. F., OosterlaanJ., van ElburgR. M.Perinatal infections and neurodevelopmental outcome in very preterm and very low-birthweight infants: a meta-analysis. JAMA Pediatr. 2013;167:662–8.
VintherA. M., HeegaardP. M., SkovgaardK., BuhlR., AndreassenS. M., AndersenP. H.Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes. J.BMC VetRes. 2016;12:83.
Zonis S., PechnickR. N., LjubimovV. A., MahgereftehM., WawrowskyK., MichelsenK. S.Chronic intestinal inflammation alters hippocampal Neurogenesis. J.Neuroinflammation. 2015;12:65.
